摘要
目的探究富血小板血浆(PRP)联合关节镜半月板成形术治疗半月板损伤的临床疗效。方法回顾性分析解放军第九七〇医院威海院区2019年11月至2021年11月的100例半月板损伤患者,根据治疗方式分为PRP组和对照组,各50例,对照组采用关节镜半月板成形术治疗,PRP组在对照组的基础上采用PRP治疗。采用卡方检验评估两组临床疗效;采用独立样本t检验评估膝关节活动度、膝关节功能、疼痛、生活质量、预后状况、血清炎症因子情况。结果PRP组总有效率为96%,高于对照组的84%(χ^(2)=4.000,P<0.05)。治疗前两组患者膝关节活动度、Lysholm膝关节功能评价量表、生活质量综合评定问卷-74评分差异均无统计学意义(均为P>0.05);治疗后两组患者膝关节活动度、Lysholm评分、生活质量综合评定问卷-74评分均升高,且PRP组高于对照组(t=3.478、5.228、3.525、10.534,均为P<0.05);与治疗前相比治疗后两组患者视觉模拟疼痛评分(VAS)均降低,且PRP组低于对照组(t=10.534,P<0.05)。PRP组患者行走辅助状况优于对照组(t=9.052,P<0.05)。治疗前两组患者血清炎症因子(C-反应蛋白、白细胞介素-6、肿瘤坏死因子-α)水平差异均无统计学意义(均为P>0.05);治疗72 h后,两组患者血清炎症因子水平均升高,但PRP组的低于对照组(t=30.423、16.718、12.110,均为P<0.001)。结论PRP联合关节镜半月板成形术治疗半月板损伤具有良好的临床疗效,能有效改善膝关节功能以及预后,减轻膝关节疼痛,提高生活质量,减轻膝关节的炎症。
Objective To investigate the clinical effect of platelet-rich plasma(PRP)combined with arthroscopic meniscus arthroplasty in the treatment of meniscus injury.Methods A retrospective analysis was made on 100 patients with meniscus injury from November 2019 to November 2021 in Weihai the 970th Hospital of PLA.According to the treatment methods,they were divided into PRP group and control group,with 50 cases in each group.The control group was treated with arthroscopic meniscus plasty,and the PRP group was treated with platelet-rich plasma(PRP)on the basis of the control group.Chi-square test was used to evaluate the clinical efficacy of the two groups;independent sample t test was used to evaluate knee joint mobility,knee joint function,pain,quality of life,prognosis and serum inflammatory factors.Results The total effective rate of the PRP group was 96%,which was higher than that of the control group(84%,χ^(2)=4.000,P<0.05).Before treatment,there was no significant difference in knee joint activity,Lysholm score or quality of life questionnaire(QOL)-74 score between the two groups(all P>0.05);after treatment,the scores of knee range of motion,Lysholm and QOL-74 were increased in both groups,and those in the PRP group were higher than those in the control group(t=3.478,5.228,3.525,10.534,all P<0.05).After treatment,the visual analogue scale(VAS)was decreased in both groups,and the VAS in the PRP group was lower than that in the control group(t=10.534,P<0.05).The assistant walking of patients in the PRP group was better than that in the control group(t=9.052,P<0.05).There was no significant difference in the level of serum inflammatory factors(C-reactive protein,interleukin-6,tumor necrosis factor-α)between the two groups before treatment(all P>0.05).After 72 h of treatment,the inflammatory factors in the two groups increased,but the PRP group were lower than the control group(t=30.423,16.718,12.110,all P<0.001).Conclusion PRP combined with arthroscopic meniscus plasty has a good clinical effect on meniscus injury,which can effectively improve knee joint function and prognosis,relieve knee joint pain,improve quality of life and reduce knee joint inflammation.
作者
夏传龙
迟健
丛强
连杰
崔峻
陈彦玲
Xia Chuanlong;Chi Jian;Cong Qiang;Lian Jie;Cui Jun;Chen Yanling(970 Hospital of the PLA JLSF,Weihai 264200,China;Zhudao Community Health Service Center,Weihai 264200,China)
出处
《中华关节外科杂志（电子版）》
CAS
CSCD
2023年第6期877-881,共5页
Chinese Journal of Joint Surgery(Electronic Edition)
作者简介
通信作者:迟健,Email:cj900203@163.com
