摘要
Pancreatic neuroendocrine neoplasms(pNENs)are rare and highly heterogeneous tumors originating from pluripotent stem cells with neuroendocrine differentiation in the pancreas,constituting approximately 3%of all pancreatic tumors.^([1])The global incidence of pNENs has been increasing recently,and most cases are sporadic and more common in women.^([1,2])pNENs are clinically divided into functioning and nonfunctioning tumors depending on whether the tumors are accompanied by a clinical syndrome related to specific hormone overproduction.
基金
supported by grants from the Shanghai Hospital Development Center(SHDC)for the promotion and management optimization of diagnosis and treatment technologies in Shanghai municipal hospitals(No.SHDC12022611)
Shanghai Key Clinical Specialty(Oncology),and Shanghai Leading Talents Project and Clinical Research Plan of SHDC(No.SHDC2020CR1035B).
作者简介
Feng Jiao,contributed equally to this work;Jiujie Cui,contributed equally to this work;Correspondence to:Prof.Liwei Wang,Department of Oncology,State Key Laboratory of Systems Medicine for Cancer,Shanghai Cancer Institute,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China,E-Mail:liweiwang@shsmu.edu.cn
