摘要
Metastases account for the overwhelming majority of cancer-associated deaths.The dissemination of cancer cells from the primary tumor to distant organs involves a complex process known as the invasion-metastasis cascade.The underlying biological mechanisms of metastasis,however,remain largely elusive.Recently,the discovery and characterization of non-coding RNAs(ncRNAs)have revealed the diversity of their regulatory roles,especially as key contributors throughout the metastatic cascade.Here,we review recent progress in how three major types of ncRNAs(microRNAs,long non-coding RNAs,and circular RNAs)are involved in the multistep procedure of metastasis.We further examine interactions among the three ncRNAs as well as current progress in their regulatory mechanisms.We also propose the prevention of metastasis in the early stages of cancer progression and discuss current translational studies using ncRNAs as targets for metastasis diagnosis and treatments.These studies provide insights into developing more effective strategies to target metastatic relapse.
基金
supported by grants from the State Key Program of the National Natural Science Foundation of China(No.81730076)
the China National Funds for Distinguished Young Scientists(No.81425019)
the Changhai Hospital Funds for Young Clinical Doctors(No.2018QNB001).
作者简介
Yi Xiao,contributed equally to this work;Yijun Hu contributed equally to this work;Correspondence to:Prof.Shanrong Liu,Department of Laboratory Diagnostics,Changhai Hospital,Naval Medical University,168 Changhai Road,Shanghai 200433,China,E-Mail:liushanrong01@126.com
