摘要
目的探讨银杏酮酯分散片联合匹伐他汀治疗老年稳定性冠心病(SCAD)的临床疗效,以及对患者血栓前状态和外周血中性粒细胞与淋巴细胞比值(NLR)、血清超敏C反应蛋白(hs-CRP)水平的影响。方法采用前瞻性研究方法,选取中国人民解放军联勤保障部队第九二八医院2019年10月至2020年12月收治的82例老年SCAD患者,使用随机数字表法分成观察组和对照组各41例。对照组患者采用匹伐他汀钙片口服治疗,观察组患者在对照组的基础上联合银杏酮酯分散片口服治疗。连续治疗8周后观察两组临床疗效。比较治疗前后两组患者的心绞痛发作情况,血栓前状态指标[D-二聚体(D-D)、纤维蛋白原(FIB)],外周血NLR、血清hs-CRP水平。并比较两组患者的不良反应发生率。结果观察组的治疗总有效率为78.05%(32/41),显著高于对照组的56.10%(23/41),差异有统计学意义(P<0.05)。两组治疗后心绞痛发作情况[每周发作次数、单次发作持续时间、严重程度(每周硝酸甘油用量)]均较治疗前显著改善(均P<0.05),且均以观察组改善更显著(均P<0.05)。治疗后,两组血浆D-D、FIB水平均较治疗前显著降低(均P<0.05),且均以观察组降低更显著(均P<0.05)。两组治疗后外周血NLR和血清hs-CRP水平均较治疗前显著下降(均P<0.05),观察组外周血NLR和血清hs-CRP水平均显著低于对照组(均P<0.05)。观察组和对照组不良反应发生率比较[9.76%(4/41)vs 7.32%(3/41)],差异无统计学意义(P>0.05)。结论银杏酮酯分散片联合匹伐他汀治疗老年SCAD的总体疗效确切,可有效改善患者的心绞痛发作、机体血栓前状态及炎症状态,安全性较好。
Objective To investigate the clinical efficacy of ginkgo biloba extract dense tablets combined with pitavastatin in the treatment of elderly stable coronary heart disease(SCAD),as well as its impact on patients′thrombotic status,neutrophil-to-lymphocyte ratio(NLR),and serum high-sensitivity C-reactive protein(hs-CRP)levels.Methods A prospective study was conducted on 82 elderly SCAD patients admitted to the 928th Hospital of PLA Joint Logistics Support Force from October 2019 to December 2020.The patients were divided into an observation group and a control group using a random number table method,with 41 patients in each group.The control group received oral pitavastatin calcium tablets,while the observation group received oral ginkgo biloba extract dense tablets on the basis of the control group.After 8 weeks of continuous treatment,the clinical efficacy of the two groups was observed.The frequency of angina attacks,thrombotic status indicators[D-dimer(D-D),fibrinogen(FIB)],peripheral blood NLR,serum hs-CRP levels were compared before and after treatment between the two groups.The incidence of adverse reactions was compared between the two groups.Results The total effective rate of the observation group was 78.05%(32/41),which was significantly higher than 56.10%(23/41)of the control group,and the difference was statistically significant(P<0.05).After treatment,the frequency of angina attacks[weekly attack times,duration of single attack,severity(weekly nitroglycerin usage)]in both groups significantly improved compared with before treatment(all P<0.05),and the observation group improved more significantly(all P<0.05).After treatment,plasma D-D and FIB levels in both groups significantly decreased compared with before treatment(all P<0.05),and the observation group decreased more significantly(all P<0.05).Peripheral blood NLR and serum hs-CRP levels in both groups significantly decreased compared with before treatment(all P<0.05),and the observation group was significantly lower than the control group(all P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group[9.76%(4/41)vs 7.32%(3/41)](P>0.05).Conclusions The overall efficacy of ginkgo biloba extract dense tablets combined with pitavastatin in the treatment of elderly SCAD is exact,which can effectively improve patients′angina attacks,thrombotic status and inflammatory state with good safety.
作者
张德杰
王姗姗
Zhang Dejie;Wang Shanshan(The 928th Hospital of PLA Joint Logistics Support Force,Haikou 570000,China)
出处
《中国医师杂志》
CAS
2023年第10期1520-1524,共6页
Journal of Chinese Physician
关键词
冠心病
银杏酮酯分散片
匹伐他汀
Coronary disease
Ginkgo ketoester dispersible tablets
Pitavastatin
作者简介
通信作者:张德杰,Email:zdj12312411@163.com
