摘要
越来越多的临床证据证实垂体前叶功能减退可导致肝硬化。垂体前叶功能减退病因包括鞍区肿瘤性疾病、遗传性疾病和围产期不良事件等。临床上,发生垂体前叶功能减退时,生长激素缺乏(GHD)常首当其冲。垂体前叶功能减退尤其是GHD,可导致肝硬化,随之而来又会次生肺、脾和心脏等多种器官功能受损。因此,其临床表现往往复杂多样,患者首诊科室各异。已有可靠的临床观察表明,在垂体前叶功能减退所致肝硬化早期阶段应用生长激素替代治疗可有效阻止和逆转肝硬化进程,甚或避免不恰当或不必要的肝脏或与肝脏相关器官的联合移植手术。多学科联动,知晓并重视垂体前叶功能减退可导致肝硬化的新发现,将有助于提高临床对肝硬化的精准诊治。
More and more clinical evidence confirms that hypopituitary dysfunction can lead to liver cirrhosis.The causes of hypopituitary dysfunction include sellarneoplastic diseases,hereditary diseases,perinatal adverse events,etc.Clinically,growth hormone deficiency(GHD)often the first cause in hypopituitary dysfunction.Hypopituitary dysfunction,especially GHD,can lead to liver cirrhosis,which in turn can result in damage to multiple organs such as the secondary lungs,spleen,and heart.Therefore,its clinical manifestations are complex,and the patients are first diagnosed in various departments.Reliable clinical observations have shown that GH replacement therapy at the early stage of the disease can effectively prevent and reverse the progression of cirrhosis,or even avoid inappropriate or unnecessary combined transplantation of liver or liver-related organs.Multidisciplinary collaboration and attention to the new findings that hypopituitary dysfunction can lead to liver cirrhosis will help to improve the accurate diagnosis and treatment of liver cirrhosis.
作者
伍学焱
张君宜
Wu Xueyan;Zhang Junyi(National Health Commission,Key Laboratory of Endocrinology,Department of Endocrinology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,100730,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2024年第4期241-246,共6页
National Medical Journal of China
基金
国家自然科学基金(81771576)
北京市自然科学基金(7202151)
关键词
垂体功能减退症
生长激素缺乏
肝硬化
Hypopituitarism
Growth hormone deficiency
Liver cirrhosis
作者简介
通信作者:伍学焱,Email:wsheyan@vip.sina.com
