摘要
To the Editor:Normal-tension glaucoma(NTG)is a progressive optic neuropathy characterized by irreversible blindness with statistically normal intraocular pressure(IOP)(≤21 mmHg),^([1,2])which makes early-stage diagnosis in the clinical practice difficult.Pathophysiological pathways underlying NTG include vascular dysregulation,toxic metabolite accumulation,and elevated translaminar cribrosa pressure difference(TLCPD).^([3])Although various small animal models have provided evidence of different pathophysiological mechanisms,the complicated clinical phenotype cannot be fully imitated by secondary disease models,and the gap between rodents and humans weakens their translational potential.Thus,the pathological changes associated with NTG remain unclear.
基金
funded by the National Key R&D Project of China(No.2020YFA0112701)
National Natural Science Foundation of China(No.82171057)
Science and Technology Program of Guangzhou,China(No.202102010216)
National Natural Science Foundation of China(No.GZR-2012-009)
Beijing Traditional Chinese Medicine Technology Development Fund Project(No.JJ-2018-50)
作者简介
Correspondence to:Yehong Zhuo,State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Sun Yat-sen University,Guangzhou,Guangdong 510060,China,E-Mail:zhuoyh@mail.sysu.edu.cn;Correspondence to:Ningli Wang,Beijing Institute of Ophthalmology,Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology&Visual Sciences Key Laboratory,Beijing 100730,China,E-Mail:wningli@vip.163.com
