摘要
急性白血病是儿童最常见的造血干细胞恶性肿瘤,位居儿童肿瘤性疾病发病率的首位,是影响儿童生长和生存的一类重大疾病。随着医疗-诊治水平不断提高、免疫治疗的广泛开展,儿童急性白血病的生存率及生活质量显著提高。近年来,我国相继成立三大儿童白血病协作组,并发表了一系列高水平研究成果。未来,着力推进儿童急性白血病诊疗规范化及同质化进程、筛选敏感残留病监测靶标、不断优化现有治疗方案、最大限度降低近/远期不良反应、探索难治/复发急性白血病最佳治疗方案、加速开展新药临床研究等,将是儿童急性白血病诊治领域的发展方向。
Acute leukemia is the most common hematopoietic stem cell malignant tumor in children,which ranks in the top one of the incidence of tumor in children,it is a major disease that affects the growth and survival of children.With the continuous improvement of medical diagnosis and treatment and the extensive development of immunotherapy,the survival rate and quality of life of children with acute leukemia have been significantly improved.In recent years,three cooperative groups of childhood leukemia have been established in China,and a series of high-level research results have been published.In the future,efforts should be made to promote the process of standardization and homogenization in the diagnosis and treatment of children′s acute leukemia,explore the monitoring targets of sensitive residual diseases,and find the best treatment for refractory/recurrent cases.Speeding up the clinical research of new drugs will be an urgent problem and development direction in the field of acute leukemia diagnosis and treatment in children.
作者
杨文钰
竺晓凡
Yang Wenyu;Zhu Xiaofan(Paediatric Haematology and Oncology Centre,State Key Laboratory of Experimental Hematology,National Clinical Research Center for Blood Diseases,Haihe Laboratory of Cell Ecosystem,Institute of Hematology&Blood Diseases Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Tianjin Institutes of Health Science,Tianjin 300020,China)
出处
《中华医学杂志》
CAS
CSCD
北大核心
2024年第27期2477-2482,共6页
National Medical Journal of China
基金
国家自然科学基金(82270144)
中国医学科学院医学与健康科技创新工程(2022-I2M-1-022)
关键词
白血病
儿童
诊断和治疗
现状
展望
Leukemia
Childhood
Diagnosis and therapy
Current situation
Prospect
作者简介
通信作者:竺晓凡,Email:xfzhu@ihcams.ac.cn
