摘要
To the Editor:Recent studies have characterized drugresistant epilepsy(DRE)as essentially a neural network disease.[1]Detection and disconnection of this pathological epileptic connectome or network can greatly improve seizure outcomes.Our team also proposes the development of the newly emerging branch of epileptic networks neurosurgery(ENN).Responsive neurostimulation(RNS)is an ENN-oriented emerging treatment option without the resection of the seizure-onset zone or epileptic focus and aims to control the seizure or other epileptic manifestations by modulating or disrupting the network’s key nodes(epileptic hubs)in a self-responsive way.
基金
supported by grants from the National Natural Science Foundation of China(Nos.82030037,81801288,and 81871009)
STI2030-Major Projects(No.2021ZD0201801)
the Translational and Application Project of Brain-inspired and Network Neuroscience on Brain Disorders,Beijing Municipal Health Commission(No.11000022T000000444685)
作者简介
Correspondence to:Guoguang Zhao,Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China,International Neuroscience Institute(China-INI),Clinical Research Center for Epilepsy,Capital Medical University,Beijing 100053,China,China National Medical Center for Neurological Diseases,Beijing 100053,China,E-Mail:ggzhao@vip.sina.com;Correspondence to:Liang Chen,Department of Neurosurgery,Huashan Hospital,Fudan University,Shanghai 200032,China,E-Mail:hschenliang@fudan.edu.cn;Correspondence to:Junming Zhu,Department of Neurosurgery,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou,Zhejiang 310009,China,E-Mail:dr.zhujunming@zju.edu.cn
