摘要
紫癜性肾炎(Henoch-Schonlein purpura nephritis,HSPN)是儿童最常见的继发性肾小球疾病,其发病机制尚未明确.近年来有研究表明肿瘤坏死因子家族新成员B细胞活化因子(B lymphocyte activaring factor,BAFF)和增殖诱导配体(a proliferation inducing ligand,APRIL)与HSPN发病相关.该文将从BAFF和APRIL的结构和生物学功能、BAFF和APRIL在HSPN发病中的作用、BAFF和APRIL靶向生物制剂治疗HSPN的展望等方面进行综述,为探讨HSPN发病机制提供参考.
Henoch-schonlein purpura nephritis(HSPN)is the most common secondary glomerular disease in children.The pathogenesis of HSPN is unclear.In recent years,there have been some reports on B lymphocyte activating factor(BAFF)and a proliferation inducing ligand(APRIL),new members of the tumor necrosis factor family,as well as their association with HSPN.This paper reviews the related research from the following aspects:structure and biological functions of BAFF and APRIL,the role of BAFF/APRIL in the pathogenesis of HSPN,the prospect of BAFF and APRIL targeted biological agents in the treatment of HSPN.It provides a reference for further research on BAFF/APRIL system and HSPN.
作者
朱万红(综述)
吴玉斌(审校)
Zhu Wanhong;Wubin(Department of Pediatrics,Shengjing Hospital of China Medical University,Shenyang 110004,China)
出处
《国际儿科学杂志》
2018年第12期933-937,共5页
International Journal of Pediatrics
关键词
紫癜性肾炎
B细胞活化因子
增殖诱导配体
Henoch-schonlein purpura nephritis
B lymphocyte activating factor
A proliferation inducing ligand
作者简介
通信作者:吴玉斌,Email:euyb@sj-hospital.org
