摘要
经还原、缩合两步反应以4-甲基-2-硝基苯胺为初始原料,在50 ℃条件下与Raney Ni(活性Ni)反应得到咖啡色粉末状对甲基邻苯二胺固体.然后将对甲基邻苯二胺在回流状态下与乙醇酸反应得到墨绿色溶液,经处理后得到的灰白色固体脱色并且干燥后得到白色粉末状的 6-甲基-2-(α-羟烷基)-1H-苯并咪唑.以及对甲基邻苯二胺在回流状态下与柠檬酸反应得到草绿色黏稠液体,经处理后得到的绿色泥状固体重结晶后得到黄色粉末状的1, 2, 3-三(5-甲基-1H-苯并咪唑-2-)-2-丙醇等4种2-(α-羟烷基)-苯并咪唑衍生物.其中有三种为新化合物.所有化合物均经熔点、IR、1HNMR或13CNMR结构确认.
Brown powdery p-methyl-phenylenediamine solid was prepared from 4-methyl-2-nitroaniline and Raney Ni at 50°C via the reduction and condensation two-step reactions.Then,p-methylphenylene diamine reacted with glycolic acid under reflux to obtain a dark green solution,and 6-methyl-2-(α-hydroxyalkyl)-1H-benzimidazole white powder was obtained via the decolorization and drying.And p-methylphenylenediamine reacted with the citric acid under reflux to obtain a grassy green viscous liquid,and four kinds of 2-(α-hydroxyalkyl)-benzidine derivatives,for example 1,2,3-tris(5-methyl-1H-benzimidazole-2-)-2-propanol,were obtained via the recrystallization.The other three derivatives were new compounds.All compounds were confirmed by melting point,1HNMR or 13CNMR.
作者
李晨阳
马圆
吴文瀚
倪洁
陈定奔
LI Chen-yang;MA Yuan;WU Wen-han;NI Jie;CHEN Ding-ben(College of Pharmaceutical and Chemical Engineering,Taizhou University,Zhejiang Taizhou 318000,China)
出处
《当代化工》
CAS
2019年第10期2313-2316,共4页
Contemporary Chemical Industry
基金
浙江省自然科学基金资助项目(Y18B020005)
作者简介
李晨阳(1997-),男,安徽亳州人,研究方向:有机合成,E-mail:ahbz.987683893@qq.com;通讯作者:陈定奔,E-mail:cdb23@163.com。
