PPARβ expression in rectus abdominis and abdominal subcutaneous fat of patients with gestational diabetes mellitus and its relationship with glucolipid metabolism 被引量：1

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摘要 Objective:To study the relationship between peroxisome proliferator-activated receptorβ(PPARβ) expression in rectus abdominis as well as abdominal subcutaneous fat of patients with gestational diabetes mellitus (GDM) and glucolipid metabolism.Methods:The pregnant women who received routine antenatal care and planned to receive selective caesarean section in Obstetrics Department of our hospital between May 2012 and March 2016 were retrospectively analyzed, and 74 healthy pregnant women and 58 pregnant women with GDM were screened and included in the control group and gestational diabetes mellitus group (GDM group) respectively. Rectus abdominis and abdominal subcutaneous fat were collected during Cesarean section to determine the expression of PPARβ was measured;peripheral blood was collected at middle-late pregnancy to determine the content of blood glucose metabolism and lipid metabolism indexes as well as adipocytokines.Results:PARβ mRNA expression and protein expression in rectus abdominis and abdominal subcutaneous fat of GDM group were significantly lower than those of control group (P<0.05);homeostasis model assessment insulin secretion index (HOMA-β), homeostasis model assessment insulin resistance (HOMA-IR) and OGTT glucose curve (AUCG) levels as well as serum low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), cholesterol (TC), Leptin, Resistin and Chemerin content of GDM group were significantly higher than those of control group (P<0.05) while early insulin secretion index (ΔI30/ΔG30) and insulin sensitive index composite (ISIcomp) levels as well as serum high-density lipoprotein cholesterol (HDL-C), Omentin-1 and Omentin-1 and adiponectin (ADPN) content were significantly lower than those of control group (P<0.05);PARβ mRNA expression and protein expression were negatively correlated with HOMA-β, HOMA IR, area under the AUCG, LDL-C, TG, TC, Leptin, Resistin and Chemerin, and positively correlated withΔI30/ΔG30, ISIcomp, HDL-C, and ADPN.Conclusions:PPARβ expression significantly decreases in rectus abdominis and abdominal subcutaneous fat of pregnant womepn with GDM and it is closely related to the abnormal glucolipid metabolism in pregnant women with GDM.

作者 Xiao-Yan Zhang Jing Tan Yi-Peng Zhang

机构地区 Obstetrics Department Laboratory Department

出处《Journal of Hainan Medical University》 2017年第1期135-138,共4页 海南医学院学报（英文版）

关键词 GESTATIONAL diabetes MELLITUS PEROXISOME proliferator-activated receptorβ INSULIN sensitivity ADIPOCYTOKINES

分类号 R5 [医药卫生—内科学]

作者简介 Corresponding author:Xiao-Yan Zhang,Obstetrics Department,Shenzhen Longhua New District Central Hospital,Shenzhen 518110,China.Tel:0755-28013201,13602632180

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