摘要
Objective:To study the correlation between helicobacter pylori infection and tumor malignancy in patients with gastric cancer.Methods:A total of 119 patients with gastric cancer treated in our hospital between May 2013 and December 2015 were collected and divided into HP-positive group (n=89) and HP-negative group (n=30) according to the combination of helicobacter pylori infection or not. RIA method was used to detect the serum angiogenesis index levels;fluorescence quantitative PCR (RT-PCR) was used to detect the mRNA expression of autophagy genes and proliferation genes in tumor tissues.Results:Serum angiogenesis indexes bFGF, VEGF and MMP-9 levels of HP-positive group were significantly higher than those of HP-negative groups;autophagy genes Beclin1, BNIP3, pULK and PI3KC3 mRNA expression in tumor tissues of HP-positive group were significantly lower than those of HP-negative group, pro-apoptotic genes Bax and p53 mRNA expression were significantly lower than those of HP-negative group, and anti-apoptotic genes PIK3CD, CIP2A and I2PP2A mRNA expression were significantly higher than those of HP-negative group. Conclusion:Helicobacter pylori infection can promote angiogenesis and cell proliferation in lesions of patients with gastric cancer.
作者简介
Corresponding author:Xiao-Bing Chen,Digestive System Department,Egang Hospital of Ezhou City Hubei Province,Ezhou City,Hubei Province,436099.Tel:0711-3231667,13986425514
