摘要
Objective: To investigate the effects of laparoscopic surgery and open surgery on serum tumor markers, coagulation function and immune function in patients with early endometrial cancer. Methods: The clinical data of 82 cases of early endometrial carcinoma were retrospectively analyzed, and they were divided into control group (n=40) and observation group (n=42) according to the treatment plan. Patients in the control group were treated with open surgery, and the observation group received laparoscopic treatment. The levels of serum tumor markers, coagulation function and immune function indexes of the two groups were compared between before operation and 1 d after operation. Results: The levels of serum CA-125, HE4, PT, APTT, FIB, CD3+, CD4+, CD8+ and CD4+/CD8+in the two groups before treatment were not significantly different. After treatment, the levels of CA-125, HE4, PT, APTT, CD3+, CD4+and CD4+/CD8+ in the two groups were significantly lower than those before treatment in the same group, and the levels of CA-125, HE4, PT and APTT in the observation group were significantly lower than those in the control group, the levels of CD3+, CD4+ and CD4+/CD8+ in the observation group were significantly higher than those of the control group;After treatment, the levels of FIB in the two groups were significantly higher than that before treatment, and the level of observation group was significantly higher than that of the control group. Conclusion: Compared with open surgery for early endometrial cancer, laparoscopic surgery can effectively reduce the level of serum tumor markers and the inhibition of immune function, however, it has great influence on coagulation function, and effective measures should be taken to prevent the formation of thrombotic diseases.
作者简介
Corresponding author:Peng-Hua Cui,Department of Gynaecology,Affiliated Hospital of Chengde Medical College,Hebei,Chengde 067000,China.Tel:18703145885 E-mail:cuipenghua47@163.com
