摘要
Objective: To study the correlation of substance P (SP) expression in diabetic foot ulcer tissue with oxidative stress and apoptosis. Methods: Patients with diabetic foot ulcer who were treated in the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology between January 2016 and March 2017 were selected as the diabetic foot ulcer (DFU) group of the research, the diabetic foot ulcer tissue samples were collected, patients who received debridement surgery due to trauma in the Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology during the same period were selected as the control group of the research, and normal wound tissue samples were collected. The contents of SP, oxidative stress molecules and apoptosis molecules in the wound specimens were detected. Results: SP, Prdx6, GSHPX and SOD contents in diabetic foot ulcer wound specimens of DFU group were significantly lower than those in normal wound specimens of control group while MDA, AOPP, Cyto-C, Caspase-9, Fas, FasL, Caspase-8 and Caspase-3 contents were significantly higher than those in normal wound specimens of control group;Prdx6, GSHPX and SOD contents in wound of patients with high SP were significantly higher than those of patients with low SP while MDA, AOPP, Cyto-C, Caspase-9, Fas, FasL, Caspase-8 and Caspase-3 contents were significantly lower than those of patients with low SP. Conclusion: The low expression of SP in diabetic foot ulcer tissue can activate oxidative stress response and apoptosis to participate in the formation of ulcer wound.
作者简介
Corresponding author:Zhong-Jing Wang,Department of Endocrinology,the Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology in Hubei Province,Wuhan City,Hubei Province,430014.Tel:027-82211474
