Study on antidepressant mechanism of Ningshenling granule

在线阅读下载PDF

导出

摘要 Objective: To explore the mechanism of Ningshenling Granule in the treatment of depression. Methods: The rat model of depression was established, and Ningshenling Granule was given orally. The morphological changes of hippocampus were observed by HE staining, and the changes of dopamine receptor D2 and CAMK2a mRNA were observed by RT-pcr. Result:Ningshenling group could significantly improve the morphological changes of pyramidal cells in hippocampus and the expressions of D2 and CAMK2a in brain tissue. Conclusion:Ningshenling can treat depression, and its mechanism is related to regulating the expression of related factors in the brain.

作者 Xiao-Jun Cai Yan-Peng Xie Zhen-Hua Lu Yan-Li Meng Jin-Hai Huo

机构地区 Heilongjiang Academy of Traditional Chinese Medicine

出处《Journal of Hainan Medical University》 2019年第3期5-8,共4页 海南医学院学报（英文版）

关键词 Ningshenling DEPRESSION The HIPPOCAMPUS DOPAMINE D2 CAMK2a

分类号 R73 [医药卫生—肿瘤]

作者简介 Corresponding author:Xiao-Jun Cai,Heilongjiang Academy of Traditional Chinese Medicine,Heilongjiang,Harbin,150036,China.

引文网络
相关文献

参考文献3

1陈旭,周晶晶,朱雪泉,冯媛.抑郁障碍的自我管理体系研究[J].中国医刊,2017,52(4):81-84. 被引量：8
2薛涛,邬丽莎,刘新民,王琼.抑郁症动物模型及评价方法研究进展[J].中国实验动物学报,2015,23(3):321-326. 被引量：63
3关宇鹏,王帅,孟宪生,李天娇,包永睿,孙婉萍.大鼠抑郁模型的建立及其综合评价研究[J].亚太传统医药,2015,11(9):3-5. 被引量：9

二级参考文献29

1李晓白,方贻儒,王祖承,井上猛,小山司.抑郁症和焦虑症动物模型的研究进展[J].上海精神医学,2004,16(4):241-243. 被引量：4
2孙欣,刘昌勤.习得性无助大鼠脚底电刺激后海马c-FOS表达[J].中国康复,2005,20(4):201-203. 被引量：1
3PORSOLT RD, LEPICHON M, JALFRE M. Depression: a new animal model sensitive to antidepressant treatment[J]. Nature,1977,266(5604) :703-732.
4POLESZAK E, WLAZ P, KEDZIERSKA E, et al. Immobil- ity stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine[J]. Phar- macological reports, 2006, 58(5): 746.
5Atsushi Sato,Osamu Nakagawasai,Koichi Tan-No,Hiroshi Onogi,Fukie Niijima,Takeshi Tadano.Effect of non-selective dopaminergic receptor agonist on disrupted maternal behavior in olfactory bulbectomized mice[J].Behavioural Brain Research.2010(2)
6Stephanie C. Dulawa,Rene Hen.Recent advances in animal models of chronic antidepressant effects: The novelty-induced hypophagia test[J]. Neuroscience and Biobehavioral Reviews . 2005 (4)
7Maj Vinberg,Jens Drachmann Bukh,Bente Bennike,Lars V. Kessing.Are variations in whole blood BDNF level associated with the BDNF Val66Met polymorphism in patients with first episode depression?[J]. Psychiatry Research . 2013
8H. Kobayashi,M. Iwata,H. Mitani,T. Yamada,K. Nakagome,K. Kaneko.Valproic acid improves the tolerance for the stress in learned helplessness rats[J]. Neuroscience Research . 2011 (4)
9Ying Xu,Zhichao Wang,Wenting You,Xiuhua Zhang,Shan Li,Philip A. Barish,Matthew M. Vernon,Xia Du,Gaowen Li,Jianchun Pan,William O. Ogle.Antidepressant-like effect of trans -resveratrol: Involvement of serotonin and noradrenaline system[J]. European Neuropsychopharmacology . 2010 (6)
10Qiong Liu,Bing Li,Hai-Yan Zhu,Yan-Qing Wang,Jin Yu,Gen-Cheng Wu.Clomipramine treatment reversed the glial pathology in a chronic unpredictable stress-induced rat model of depression[J]. European Neuropsychopharmacology . 2009 (11)

共引文献74

1Xiao-Jun Cai,Zhen-Hua Lu,Yan-Li Meng,Jin-Hai Huo.Effect of Ningshenling Granule on apoptosis, autophagy and oxi-dative stress injury of hippocampal neurons in depression model rats[J].Journal of Hainan Medical University,2019,25(23):2-5.
2吕兰兰,倪龙燕,闫伟,张荣荣,谢世平.抑郁障碍量化治疗模式研究进展[J].国际精神病学杂志,2018,45(6):994-997. 被引量：2
3章主恒,王静,付宇,乐江.中药远志抗抑郁有效成分及其作用机制研究进展[J].中国中医基础医学杂志,2018,24(12):1797-1801. 被引量：30
4于淼,张丹妹,邬继红,图娅,史榕荇,许明敏,郭郁,张旭辉,王瑜,张春涛,赵冰骢.电针对慢性应激抑郁模型大鼠海马神经血管生成相关蛋白的表达影响[J].环球中医药,2016,9(4):385-390. 被引量：4
5宗阳,朱立静,孙冰婷,张倩,居文政.利血平诱导的抑郁模型的研究进展[J].中国药房,2016,27(19):2697-2699. 被引量：18
6景泉凯,赛音朝克图,姚海江,吕威,奥村悠斗,杨利娟,刘俊彤,李志刚.电针对慢性应激抑郁模型大鼠海马磷酸二酯酶4及其亚型表达的影响[J].中国康复理论与实践,2016,22(9):1011-1014. 被引量：9
7张北月,卢聪,董黎明,徐攀,何怡然,石晋丽,刘新民.不同时长的束缚应激致雌雄大鼠的抑郁样行为改变[J].中国比较医学杂志,2016,26(11):18-23. 被引量：4
8石昌杰,花秋红,张丽红,张儒.神经干细胞特异性LSD1基因敲除对小鼠情绪及记忆的影响[J].中国实验动物学报,2017,25(1):79-84. 被引量：1
9宋洪涛,武忠,张瑞霞,赛音朝克图,景泉凯,姚海江.慢性应激对大鼠凝血功能和血小板活化的影响及电针的干预作用[J].中国康复理论与实践,2017,23(3):304-307. 被引量：8
10孟盼,朱青,张秀丽,向韵,王宇红,杨蕙,雷昌.海马内微量注射K252a对大鼠行为学及抑郁样经典指标的影响[J].中国比较医学杂志,2017,27(4):26-33. 被引量：1

1SUN Yi,CHEN Yu-fei,SHANG Hao,HE Ling.NP-11 Keap1-Nrf2 Inhibitor NXPZ Ameliorated Aβ1-42-Induced Cognitive Dysfunction in Mice[J].神经药理学报,2018,8(4):109-110.
2方星,桑明,张帆,宋金辉,王普清.DRD2基因多态性与帕金森病的相关性分析[J].湖北医药学院学报,2019,38(1):26-29. 被引量：2
3Hao Ma,Weiping Wang,Shaofeng Xu,Ling Wang,Xiaoliang Wang.Potassium 2-(1-hydroxypentyl)-benzoate improves depressive-like behaviors in rat model[J].Acta Pharmaceutica Sinica B,2018,8(6):881-888. 被引量：4
4Luo Xiaozhou,Huang Jianting,Yu Juan,Tang Chunzhi.Effect of Taichong(LR 3) acupuncture in spontaneously hypertensive rats[J].Journal of Traditional Chinese Medicine,2019,39(1):74-80. 被引量：4
5LUO Qi-chao,CHEN Li-ping,CHENG Xi,MA Yu-qin,LI Xiao-na,ZHANG Shi-lei,LI Yang,YANG Huai-yu.Novel antidepressants targeting TREK1 channel[J].中国药理学与毒理学杂志,2018,32(9):729-730.
6Jie Zhao,Wenlong Li,Haibin Qu,Geng Tian,Yanding Wei.Application of defin让ive screening design to quantify the effects of process parameters on key granule characteristics and optimize operating parameters in pulsed-spray fluid-bed granulation[J].Particuology,2019,17(2):56-65. 被引量：9
7I failed[J].英国医学杂志中文版,2019,22(3):158-158.
8Lu Zhang,Yi-Xuan Liu,Zhe Wang,Xiao-Qi Wang,Jing-Jing Zhang,Rong-Huan Jiang,Xiang-Qun Wang,Shi-Wei Zhu,Kun Wang,Zuo-Jing Liu,Huai-Qiu Zhu,Li-Ping Duan.Clinical characteristic and fecal microbiota responses to probiotic or antidepressant in patients with diarrhea-predominant irritable bowel syndrome with depression comorbidity: a pilot study[J].Chinese Medical Journal,2019(3):346-351. 被引量：5
9倪瑾瑶,陈晓湖,缪成锋,徐菲菲,陈国荣,蔡国平.肺腺癌中ALK基因重排的检测[J].中国应用生理学杂志,2019,35(2):113-116.
10Omar ME Abdel-Salam.Prevalence, clinical features and treatment of depression in Parkinson's disease: An update[J].World Journal of Neurology,2015,5(1):17-38. 被引量：1

Journal of Hainan Medical University

2019年第3期

浏览历史

内容加载中请稍等...

Study on antidepressant mechanism of Ningshenling granule

参考文献3

二级参考文献29

共引文献74

相关作者

相关机构

相关主题

浏览历史