摘要
目的:比较分析托拉塞米和呋塞米治疗慢性心衰的临床效果及安全性。方法对2011年10月~2013年10月我院收治106例慢性心衰患者进行随机双盲分组,托拉塞米组和呋塞米组各53例,对治疗前后两组心功能、水肿情况、体重变化及不良反应情况进行比较分析。结果两组患者治疗后心功能均明显改善,体重下降,水肿减轻,组间差异无统计学意义(P>0.05),托拉塞米组治疗24h平均尿量到达(2159±824.5)ml,高于呋塞米组的(1893±759.5)ml,组间差异具有统计学意义(P<0.05)。托拉塞米组有12例出现不良反应,呋塞米组有12例出现不良反应,两组不良反应发生率差异无统计学意义(P>0.05)。结论托拉塞米和呋塞米治疗慢性心衰疗效确切,均可有效改善心功能,减轻水肿,托拉塞米短期利尿作用更强,低钾的慢性心力衰竭更加适用。
Objective:To compare the analysis of torasemide and furosemide treatment of chronic heart failure clinical ef icacy and safety.Methods:October 2011 to October 2013 in our hospital 106 cases of chronic heart failure patients randomized,double-blind group,furosemide torsemide group and each group 53 cases,the two groups before and after treatment of cardiac function,edema cases,weight change and adverse reactions were compared.Results:The two groups of patients after treatment were significantly improved cardiac function,weight loss,edema,between the two groups was not statistical y significant(P>0.05)dif erence in average Torasemide 24h urine therapy group arrives(2159±824.5)ml,higher than furosemide group(1893±759.5)ml,the dif erence was statistical y significant(P<0.05)between groups.Torasemide group,12 cases of adverse reactions,furosemide group had 12 cases of adverse reactions,adverse reaction rate between the two groups was not statistical y significant(P>0.05).Conclusion:torasemide and furosemide is ef ective in treating chronic heart failure can ef ectively improve the cardiac function,reduce edema,Torasemide short-term diuretic ef ect stronger,more suitable for chronic heart failure hypokalemia.
作者
茅永翠
MAO Yong-cui(Jiangsu Province Qidong City Third People's Hospital,Qidong Jiangsu 226200,China)
关键词
托拉塞米
呋塞米
慢性心衰
Torasemide
Furosemide
Chronic heart failure
