摘要
目的观察红蓝光联合螺内酯治疗女性成人痤疮的疗效。方法选择2011年6月~2013年3月在淳安县第一人民医院皮肤科就诊的62例女性成人痤疮患者,给予患者红蓝光照射联合螺内酯片口服。在基线、治疗后4w与8w计数粉刺与炎症性损害(丘疹、脓疱、结节)的数目。在基线与治疗后8w记录疾病严重度视觉模拟评分(VAS)。结果治疗4w后,粉刺与炎症性皮损数目分别较基线减少了44.56%(=25.89,<0.01)与50.47%(=25.40,<0.01);治疗8w后,粉刺与炎症性皮损数目分别较基线减少了65.90%(=33.14,<0.01)与77.45%(=28.15,<0.01),VAS评分较基线减小了35.70%(=18.76,<0.01)。结论红蓝光照射联合螺内酯治疗女性成人痤疮疗效显著。
Objective To observe the clinical efficacy of Blue and red light combined with spironolactone in the treatment of female adult acne.Methods 62 female adult patients with mild to moderate acne vulgaris who attended the dermatology outpatient of First People's Hospital of Chun'an were selected,and given blue and red light therapy combined with oral spironolactone.Comedones and inflammatory lesions(papules,pustules and nodules were considerd as inflammatory lesions)were countd at baseline and 4&8 weeks post therapy,respevtively.Visual analogue scale(VAS)of disease severity were recorded at baseline and 8 weeks post therapy.Results A mean improvement of 44.56%(=25.89,<0.01)and 50.47%(=25.40,<0.01)from baseline in comedones and inflammatory lesions were achieved 4 weeks post therapy;and a mean improvement of 65.90%(=33.14,P<0.01)and 77.45%(=28.15,<0.01)were achieved 8 weeks post therapy,respectively.After 8 weeks'therapy,VAS of disease severity decreased 35.70%(=18.76,<0.01)from baseline.Conclusion Blue and red light combined with spironolactone were highly ef ective in the treatment of female adult acne of mild to moderate severity.
作者
单靓云
吴大兴
SHAN Liang-yun;WU Da-xing(The First People's Hospital of Chun'an County,Chun'an 311700,Zhejiang,China)
关键词
成人痤疮
女性
红蓝光
螺内酯
Adult acne
Female
Blue and red light
Spironolactone
