摘要
目的了解妊娠期间存在亚北方甲状腺功能减退症妇女甲状腺素替代治疗的临床观察。方法对2009年1月~2013年12月在我医院门诊,妊娠12w妇女常规筛查测定FT3、FT4、TSH、TPO-Ab,确诊亚临床甲状腺功能减退,给予左甲状腺素钠LT4替代治疗。结果入选符合标准的患者共38例妇女LT4用量25~187.5ug/d,其中13例孕期开始服用LT4,剂量为25~100ug/d,23例孕前服用LT4治疗妇女,妊娠期间继续LT4治疗,计量较孕前增加(41.2依24)12.5~87.5ug/d,平均增加了83依65(20%~300%)。结论亚临床甲状腺功能减退症对妊娠结果和后代神经发育的影响,近年来引起内分泌、围产医学和优生学界的高度重视。无论孕前甲状腺功能状态如何,发现妊娠时都应及早评估甲状腺功能状态,及时发现亚临床甲状腺功能减退。先给予足量甲状腺素治疗,或及时增加甲状腺素用量,以确保甲状腺功能正常状态。
Objective To investigate the during pregnancy,sub boreal hypothyroidism in the clinical observation of treatment of women with thyroid hormone replacement.Methods During the 2009.1-2013.12 in our hospital,12 weeks of pregnancy women routine screening for determination of FT3,FT4,TSH,TPO-Ab,subclinical hypothyroidism diagnosed decline,given levothyroxine sodium LT4 replacement therapy.Results The selected in accordance with the standards of the patients with a total of 38 cases of women with LT4 dosage of 25~187.5ug/d,including 13 cases of pregnancy to start taking LT4,dose of 25-100ug/d,23 cases of pregnant women with LT4 treatment,LT4 treatment during pregnancy to continue,measurement is pre pregnancy increased(41.2±24)12.5~87.5ug/d,the average increased by 83±65(20%~300%).Conclusion Subclinical hypothyroidism af ect the results and offspring neurodevelopmental pregnancy,in recent years caused by endocrine,Wai attaches great importance to science and eugenics circles.No mat er how thyroid function pre pregnancy,pregnancy should be found early assessment of thyroid function,timely detection of subclinical hypothyroidism.Give enough thyroid hormone therapy,or to add the thyroxine dosage,to ensure the normal thyroid function status.
作者
李澜
杨瑜
孙丹丹
王雨
LI Lan;YANG Yu;SUN Dan-dan;WANG Yu(Inner Mongolia North Heavy Industries Hospital,Baotou 014030,Inner Mongolia,China)
