摘要
目的探讨血清中白介素-8(IL-8)、白介素-10(IL-10)和降钙素原(PCT)在小儿肺炎支原体肺炎发病中的临床价值。方法用ELISA法和化学发光法检测62例肺炎支原体肺炎患儿治疗前后及50例同期幼儿园和小学生健康体检者血清中IL-8、IL-10和PCT水平,结合临床相关检查资料,对检测结果采用SPSS18.0统计软件进行统计学分析,各组实验数据以均数±标准差(±)表示,各实验组间比较计量资料的t检验,<0.05为有统计学意义。结果 MPP组治疗前:IL-8(16.38±9.63 pg/ml)、IL-10(13.59±8.41 pg/ml)、PCT(0.68±0.52 mg/L)与对照组IL-8(4.66±3.92 pg/ml)、IL-10(5.67±3.03 pg/ml)、PCT(0.29±0.16 mg/L)浓度比较有显著性差异(<0.05);MPP组治疗6~8d后IL-8(5.15±4.49 pg/ml)、IL-10(6.42±5.06 pg/ml)、PCT(0.31±0.18 mg/L)浓度较治疗前均有明显下降,有显著性差异(<0.05),与健康对照组比较,两者差异无统计学意义(>0.05)。结论 MPP患儿入院治疗前、治疗后血清IL-8、IL-l0,PCT含量的变化对疾病的进展和疗效有一定指导意义,提示IL-8、IL-10和PCT在MPP发病机制中起重要作用。
Objective To explore the clinical application of serum IL-8、IL-10 and PCT in children with Mycoplasma Pneumonia(MPP).Methods The levels of serum IL-8、IL-10 and PCT of 62 cases of children with MPP、50 health students as control group were detected by ELISA or chemiluminescence assay at the same time.The clinical relative factors and experimental data were statistical y analyzed using SPSS18.0 statistical software,each set of experimental data expressed as mean±standard deviation,in each experimental group were analyzed by using t-test,<0.05 was considered statistical y significant.Results The levels of serum IL-8、IL-10 and PCT of MPP children(IL-8(16.38±9.63 pg/ml)、IL-10(13.59±8.41 pg/ml)、PCT(0.68±0.52 mg/L)were remarkably higher than those in control group(IL-8(4.66±3.92 pg/ml)、IL-10(5.67±3.03 pg/ml)、PCT(0.29±0.16 mg/L),<0.01 After 6-8 days treatment,the levels of serum IL-8、IL-10 and PCT of MPP children were remarkably decreased and have no significant dif erence with those in control group.Conclusion The change of serum IL-8、IL-10 and PCT in children with MPP during the treatment indicates that serum IL-8、IL-10 and PCT play an important ef ect in the pathogenesis of MPP.
作者
张虹
顾猛
ZHANG Hong;GU Meng(Medical Laboratory,Nantong RICH Hospital,Nantong226009,Jiangsu,China;Medical Laboratory,The Affiliated Hospital of Nantong,University,Children's Hospital of Changzhou,Changzhou213003,Jiangsu,China)
