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肺癌脑转移患者治疗采用替莫唑胺联合方案与拓扑替康卡铂方案的对比研究

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摘要 目的:肺癌脑转移患者治疗采用替莫唑胺联合方案与拓扑替康卡铂方案对比研究。方法选择142例合并脑转移的非小细胞肺癌(non-small lung cancer,NSCLC)患者接受治疗,其中替莫唑胺联合方案组68例,拓扑替康卡铂方案组74例。结果替莫唑胺组总有效率48.496%,中位生存期10.1个月;拓扑替康组总有效率45.683%,中位生存期9.2个月。两组有效率无统计学差异(P>0.05);两组生存期无统计学差异(P>0.05)。骨髓抑制为主要不良反应,两组比较无统计学差异(P>0.05)。结论采用替莫唑胺联合方案治疗肺癌脑转移与采用拓扑替康卡铂方案相比,其疗效肯定,且与拓扑替康卡铂方案组在近期疗效和长期生存率方面相似,耐受性较好。
作者 付红
出处 《临床研究》 2014年第6期72-72,共1页 Clinical Research
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