摘要
目的 观察中心静脉导管0~96h封管液时间分段梯度浓度,总结封管液的浓度-时间的变化规律. 方法 导管垂直置于l000ml二级反渗水的烧瓶内,向导管静脉端注入等标量容积的封管液.从导管尖端到尾部依次分为6段留取标本,此过程重复10次.计算出平均浓度,描绘出浓度-时间曲线图,进行4参数模型曲线拟合求出参数. 结果 封管后即刻,导管尖段残存浓度为(15.8±0.8)mmol/L,5min时快速下降到(9.9±0.9)mmol/L,然后缓慢下降到96h的(0.7±0.1)mmol/L;第2段的残存浓度从即刻的(22.4±0.6)mmol/L逐渐下降到96h的(2.7±0.4)mmol/L;第1至第6段下降速度依次变慢,96h时第4、5和6段残存浓度相似.拟合方程Y=(A-D)/[1+(T/C)B] +D能啮合药时曲线图(R2>90). 结论 封管后即刻管尖端封管液即己流失,在5min内快速流失,封管液浓度明显下降.可根据拟合方程推算出临床上合适的封管液浓度和有效作用时间从而制定合理的封管策略.
Objective To observe the gradient concentration of sealing fluid sealed in central vein catheters for 0-96 hours,and to summarize the concentration-time changing rule of the sealing fluid.Methods A catheters was placed vertically in a flask containing 1,000 ml reverse-osmosis water of secondary grade.The scaled volume of sealing fluid was injected into the venous end of the catheter.Samples were collected from tip to tail of the catheter in six parts,and the procedure was repeated 10 times.The average concentration was calculated,the concentration-time curve was drawn,and the parameters were obtained by fitting the four-parameter model curve.Results Immediately after tube closure,the concentration remained in the tip segment was 15.8±0.8 mmol/L,rapidly decreased to 9.9±0.9 mmol/L in 5 minutes,then slowly decreased to 0.7±0.1 mmol/L after 96 hours.The concentration remained in the second segment gradually decreased from 22.4±0.6 mmol/L immediately after tube closure to 2.7±0.4 mmol/L after 96 hours.The decline rate slowed down along the first to sixth segments.The concentration of remained sealing fluid was similar in the fourth,fifth and sixth segments after 96 hours.Fitting equation Y=(A-D)/[1+(T/C)~B]+D can mesh with the propellant curve(R^2>90).Conclusion Immediately after sealing,the sealing fluid at the tip of the tube lost and quickly and further lost within 5 minutes,associated with significant decrease of sealing fluid concentration.According to the fitting equation,the suitable concentration and effective time of sealing fluid can be calculated and a reasonable sealing strategy can be worked out.
作者
张国胜
焦夏
吝泽华
左力
ZHANG Guo-sheng;JIAO Xia;LIN Ze-hua;ZUO Li(lDepartment of Nephrology,PekingUniversityPeoplejsHospital,Beij'ing 100044,China;Department of Nephrology,Zhengzhou Traditional Chinese Medicine Hospiml Affiliated to Henan University of Traditional Chinese Medicine,Zhengzhou 15000Z China;Department ofNe—phrology,Yuncheng Tongde Hospital,Yuncheng 044000,China;Department ofNephrology,Beijing Boai Hos—pital,Beijing 100068,China)
出处
《中国血液净化》
CSCD
2019年第8期564-567,共4页
Chinese Journal of Blood Purification
关键词
中心静脉导管
封管液
残存率
Central venous catheter
Sealing fluid
Remaining rate
作者简介
通讯作者:左力,Email:zuoli@bjmu.edu.cn
