重组组织型纤溶酶原激活剂溶栓联合阿司匹林对急性脑梗死患者神经功能的影响被引量：4

Effect of Recombinant Tissue Plasminogen Activator Thrombolysis Combined with Aspirin on Neurological Functions in Patients with Acute Cerebral Infarction

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摘要目的:探讨重组组织型纤溶酶原激活剂(rtPA)溶栓联合阿司匹林对急性脑梗死患者神经功能的影响.方法:选取2016年3月—2018年3月我院收治的急性脑梗死患者64例,按照随机数字表法分成对照组和观察组,各32例,对照组给予阿司匹林肠溶片(100 mg,qd)治疗,观察组给予rtPA溶栓(0.9 mg/kg)联合阿司匹林治疗,比较两组治疗效果、美国国立卫生研究院卒中量表(NIHSS)评分、Barthel指数及不良反应情况.结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后NIHSS评分较对照组低,Barthel指数较对照组高,差异有统计学意义(P<0.05);观察组不良反应总发生率较对照组低,差异有统计学意义(P<0.05).结论:rtPA溶栓结合阿司匹林治疗急性脑梗死可有效提高治疗效果,改善患者的神经功能及日常生活能力,同时降低不良反应发生率. Objective:To investigate the effect of recombinant tissue plasminogen activator(rtPA)thrombolysis combined with aspirin on neurological functions in patients with acute cerebral infarction.Methods:64 patients with acute cerebral infarction admitted to our hospital from March 2016 to March 2018 were selected and randomly divided into a control group and an observation group,32 cases each.The patients in the control group were given aspirin entericcoated tablets(100),and the patients in the observation group were given rtPA thrombolysis(0.9 mg/kg)combined with aspirin.The therapeutic effect,NIHSS scores,Barthel index and adverse reactions were compared between the two groups.Results:The total effective rate in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The NIHSS scores in the observation group were lower than those in the control group,while the Barthel index was higher than that in the control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion:rtPA thrombolysis combined with aspirin can effectively improve the treatment effect,improve patients’neurological functions and daily living ability and reduce the incidence of adverse reactions in the treatment of acute cerebral infarction.

作者徐连营李庆全 Xu Lian-ying;Li Qing-quan(Department of Neurology,Nanyang Second People’s Hospital,Nanyang Henan 473000,China)

机构地区河南省南阳市第二人民医院神经内科

出处《中国合理用药探索》 CAS 2019年第6期41-43,共3页 Chinese Journal of Rational Drug Use

关键词急性脑梗死重组组织型纤溶酶原激活剂溶栓阿司匹林神经功能日常生活能力不良反应 Acute Cerebral Infarction Recombinant Tissue Plasminogen Activator Thrombolysis Aspirin Neurological Function Daily Living Ability Adverse Reaction

分类号 R743.3 [医药卫生—神经病学与精神病学]

作者简介通讯作者:徐连营,男,副主任医师。研究方向:脑血管临床。E-mail:xuliany@163.com