摘要
目的 探讨老年重度阻塞性睡眠呼吸暂停综合征(obstructive sleep apnea syndrome,OSAS)患者同型半胱氨酸(homocysteine,HCY)水平与认知功能的关系.方法 选取浙江医院2017年10月至2018年4月收治的老年重度OSAS患者30例(OSAS组)以及同期老年健康体检健康者30例(对照组),两组患者均行多导睡眠图(polysomnography,PSG)监测,并行血浆HCY测定及简易智力状态检查量表(mini mental state examination,MMSE)评分.比较两组对象睡眠呼吸暂停低通气指数(apnea hypopnea index,AHI)、最低氧饱和度(minimum oxygen saturation,LSO2)、平均氧饱和度(mean oxygen saturation,MSO2)、MMSE评分及HCY水平,并作相关性分析.组间比较采用t检验,相关关系采用Pearson相关分析.结果 OSAS组患者AHI及HCY水平均显著高于对照组健康者(t=29.169、4.132,均P<0.01),LSO2、MSO2、MMSE评分均显著低于对照组健康者(t=11.045、11.521、6.774,均P<0.01).OSAS患者AHI、LSO2、MSO2与MMSE评分和HCY水平均无明显相关性(r=0.163、0.265、0.161,0.142、0.027、0.076;均P>0.05),MMSE评分与HCY水平亦无明显相关性(r=0.203,P>0.05).结论 老年OSAS患者的认知障碍是由多因素、多环节导致的,HCY水平升高可能是其危险因素之一.
Objective To investigate the relationship between homocysteine level and cognitive function in elderly patients with severe obstructive sleep apnea syndrome(OSAS).Methods 30 elderly patients with severe OSAS and 30 controls were recruited from October 2017 to April 2018 in Zhejiang Hospital,they were monitored by polysomnography(PSG),serum HCY levels were tested,cognitive function was measured by mini mental state examination(MMSE).The apnea hypopnea index(AHI),minimum oxygen saturation(LSO2),mean oxygen saturation(MSO2),MMSE score and HCY level were compared between the two groups,and correlation analysis was performed.The T test was used for comparison between groups,and the correlation was analyzed by Pearson correlation analysis.Results The levels of AHI and HCY in OSAS patients were significantly higher than those in controls(t=29.169,4.132,P<0.01),and LSO2,MSO2,and MMSE scores were significantly lower than those in the control group(t=11.045,11.521,6.774,P<0.01).There was no significant correlation between AHI,LSO2,MSO2 and MMSE scores and HCY levels in OSAS patients(r=0.163,0.265,0.161,0.142,0.027,0.076,P>0.05),and there was no significant correlation between MMSE score and HCY level(r=0.203,P>0.05).Conclusion Cognitive impairment in elderly patients with OSAS is caused by multiple factors and links,the increased HCY level may be one of the risk factors.
作者
陆晓玲
钦光跃
黄勍栋
唐婷玉
杜坚宗
Lu Xiaoling;Qin Guangyue;Huang Qingdong;Tang Tingyu;Du Jianzong(Department of Respiratory,Zhejiang Hospital,Hangzhou 310013,China)
出处
《中华老年病研究电子杂志》
2019年第2期40-43,共4页
Chinese Journal of Geriatrics Research(Electronic Edition)
基金
浙江省医药卫生科技计划项目(2015KYB011、2018KY203)
作者简介
通信作者:钦光跃,Email:54886084@qq.com
