摘要
目的 探讨抗SmD1抗体与系统性红斑狼疮(SLE)疾病活动及狼疮肾炎的相关性.方法 使用线性免疫印迹法测定49例系统性红斑狼疮患者和77例其他非狼疮的风湿性疾病患者及40名健康体检者血清中抗SmD1抗体.同时记录SLE疾病活动指数(SLEDAI)、相关自身抗体和实验室指标.结果 抗SmD1抗体诊断SLE的特异性和敏感性分别92.5%、69.4%.抗SmD1抗体与肾损害及浆膜炎存在显著相关.而与中枢神经系统、关节、皮肤及肺等靶器官的损伤等差异无统计学意义.抗SmD1抗体与SLEDAI呈正相关(P<0.05).抗SmD1抗体对诊断系统性红斑狼疮疾病活动的特异性和敏感性分别为71.4%、85.7%.结论 抗SmD1抗体有较高的特异性和敏感性,可作为诊断SLE的参考指标.血清抗SmD1抗体与SLE病情活动有显著相关性,并与肾损害及浆膜炎密切相关.
Objective To investigate the relationship between the presence of anti-SmD1 antibodies(Ab)with disease activity and renal involvement in patients diagnosing systemic lupus erythematosus(SLE). Methods Anti-SmD1 Ab were measured by Line Immuno Assay(LIA) in 49 patients with SLE. 40 healthy blood donors and 77 other connective tissue diseases patients were included in the control group. Results The specificity and sensitivity of anti-SmD1Ab in the diagnosis of SLE were 92.5% and 69.4%. The anti-SmD1 Ab had relationships with the kidney damage and serositis significantly. But there were no obvious relationships with central nervous system,arthritis,skin and lung damage. The presence of anti-SmD1 Ab was positively correlated with systemic lupus erythematosus Disease Activity Index,(SLEDAI)(P<0.05). The specificity and sensitivity of anti-SmD1Ab in the estimate of SLEDAI were 71.4%,85.7%. Conclusion Anti-SmD1 antibody has high specificity and sensitivity, and can be used as a reference index for the diagnosis of SLE. Serum anti-SmD1 antibody was significantly correlated with SLE activity, renal damage and serositis.
出处
《浙江临床医学》
2019年第3期308-309,312,共3页
Zhejiang Clinical Medical Journal
基金
浙江省温州市科技局项目(Y20170310).
关键词
抗SMD1抗体
狼疮疾病活动
狼疮肾炎
浆膜炎
Anti-SmD1 antibodies
Systemic lupus erythematosus disease activity
Lupus nephritis
Serositis
