摘要
目的 分析急危重症有机磷中毒患者采用血液灌流治疗的临床价值.方法 选取滨州市中心医院2017年1月至2018年12月诊治的68例急危重症有机磷中毒患者,以随机数字表法分为观察组和对照组,每组34例.对照组采取常规治疗方案,观察组在常规治疗基础上联合应用血液灌流方案治疗.比较两组的治疗效果及治疗前后血清炎性因子[白细胞介素-1(IL-1)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)]的改善情况.结果 观察组患者经抢救治疗的总有效率为97.06%(33/34),高于对照组的85.29%(29/34),P<0.05;观察组意识恢复、阿托品化、胆碱酯酶(CHE)活力恢复、机械通气及住院治疗时间均短于对照组(P均<0.05).治疗前,两组患者IL-1、TNF-α、CRP比较差异未见统计学意义(P>0.05);治疗后,观察组IL-1、TNF-α、CRP水平低于对照组(P<0.05).结论 在急危重症有机磷中毒患者治疗中采用血液灌流治疗可取得满意效果,有助于改善患者血清炎性因子水平并提高急救效果.
Objective To analyze the clinical value of hemoperfusion in the treatment of patients with acute and severe organophosphorus poisoning.Methods Sixty-eight critically ill patients for organophosphorus poisoning hospitalized in Binzhou Central Hospital from January 2017 to December 2018 were selected and divided into observation group and control group by random number table method,with 34 case in each group.Patients in control group were treated by conventional treatment,and patients in observation group were treated by hemoperfusion on the basis of conventional treatment.The therapeutic effects of the two groups were compared,and the improvement of serum inflammatory factors,such as interleukin-1(IL-1),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)of the two groups before and after treatment were compared.Results The total effective rate was 97.06%(33/34)in observation group,higher than 85.29%(29/34)in control group(P<0.05).The recovery time of consciousness,atropinization time,recovery time of cholinesterase(CHE)activity,mechanical ventilation time and hospital stay in observation group were shorter than those in control group(P<0.05).Before treatment,there was no significant difference in IL-1,TNF-αand CRP between the two groups(P>0.05).After treatment,the levels of IL-1,TNF-αand CRP in observation group were lower than those in control group(P<0.05).Conclusions Hemoperfusion can achieve satisfactory results in the treatment of critically ill patients for organophosphate poisoning.It is helpful to improve the level of serum inflammatory factors and improve the emergency treatment effects.
作者
杨涛
何新泽
王成刚
Yang Tao;He Xinze;Wang Chenggang(Department of Emergency,Binzhou Central Hospital,Binzhou 251700,China)
出处
《中国实用医刊》
2019年第19期87-89,共3页
Chinese Journal of Practical Medicine
关键词
重症有机磷中毒
血液灌流
急救
胆碱酯酶
效果
Severe organophosphorus poisoning
Hemoperfusion
Emergency treatment
Cholinesterase
Effect
作者简介
通信作者:杨涛,Email:zhwvbin@sohu.com
