摘要
Importance:Nasal nitric oxide(nNO)testing is a method used in the diagnosis of primary ciliary dyskinesia(PCD).It has not been evaluated in Chinese population.Objective:To establish a reference nNO value to assist in the diagnosis of PCD in Chinese children.Methods:nNO values were measured in children with PCD(n=36),cystic fibrosis(CF)(n=20),asthma(n=45),post-infectious bronchiolitis obliterans(BO)(n=41)and non-PCD/non-CF bronchiectasis(n=32).The receiver operating characteristic nNO value for the diagnosis of PCD was plotted and the area under the curve was calculated.Results:nNO values were significantly lower in children with PCD(median 25.66 nL/min)than in children with asthma(186.26±58.95 nL/min),BO(143.47±49.71 nL/min)and non-PCD/non-CF bronchiectasis(173.13±63.80 nL/min),but not in children with CF(90.90±43.20 nL/min).Notably however,no CF patient had an nNO value<45 nL/min.A cut-offof 76 nL/min yielded the best sensitivity of 86.1%,and specificity of 91.4%,with an area under the curve of 0.920(95%confidence interval 0.859-0.981)for the diagnosis of PCD.If CF was ruled out the specificity increased to nearly 100%.Interpretation:nNO testing is able to discriminate between patients with PCD and those with CF,asthma,post-infectious BO and non-PCD/non-CF bronchiectasis.A cut-off of 76 nL/min could be further examined in patients suspected of PCD,to establish an nNO reference value for PCD screening in Chinese children.
作者简介
corresponding author:ShunYing Zhao.The Second Department of Respiratory Medicine,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045.China Email:zhaoshunying2001@163.com
