摘要
目的探讨托吡酯联合丙戊酸钠治疗癫痫患者的疗效及对睡眠质量的影响.方法通过便利抽样法选取2019年1月—2020年7月该院神经内科收治的82例癫痫患者为研究对象,按随机数字表法分为研究组与对照组,每组41例.对照组采用丙戊酸钠治疗,研究组在对照组基础上联合使用托吡酯治疗.对两组患者的治疗效果、症状改善情况、治疗前后睡眠质量以及不良反应发生情况进行对比分析.结果两组治疗总有效率比较,研究组高于对照组,差异有统计学意义(P<0.05).两组治疗前的匹兹堡睡眠质量指数量表(pittsburgh sleep quality index,PSQI)评分比较,差异无统计学意义(P>0.05);与治疗前相比,两组治疗后的PSQI评分降低,差异有统计学意义(P<0.05);治疗后,与对照组相比,研究组的PSQI评分明显更低,组间差异有统计学意义(P<0.05).研究组癫痫发作持续时间、发作控制时间、意识恢复时间均短于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论针对癫痫患者实施托吡酯联合丙戊酸钠治疗的临床效果确切,有助于调节神经递质分泌,改善睡眠质量,安全性较高,值得应用.
Objective To explore the effect of topiramate combined with sodium valproate in the treatment of patients with epilepsy and its effect on sleep quality.Methods 82 epilepsy patients admitted to the neurology department of the hospital from January 2019 to July 2020 were selected by convenience sampling method as the research objects,and were divided into study group and control group according to the random number table method,with 41 cases in each group.The control group was treated with sodium valproate,and the study group was treated with topiramate in combination on the basis of the control group.The treatment effect,symptom improvement,sleep quality before and after treatment and adverse reactions of the two groups were compared and analyzed.Results Comparing the total effective rate of treatment between the two groups,the study group was higher than the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the pittsburgh sleep quality index(PSQI)scores before treatment between the two groups(P>0.05);compared with before treatment,the PSQI scores of the two groups were reduced after treatment,and the difference was statistically significant(P<0.05);after treatment,compared with the control group,the PSQI score of the study group was significantly lower,and the difference between the groups was statistically significant(P<0.05).The duration of epileptic seizures,seizure control time,and consciousness recovery time in the study group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The clinical effect of topiramate combined with sodium valproate treatment for patients with epilepsy is definite,which helps to regulate neurotransmitter secretion,improve sleep quality,and has high safety and is worthy of application.
作者
梁艳
刘肖
邱敬锦
邓莉
LIANG Yan;LIU Xiao;QIU Jingjin;DENG Li(Second District,Department of Neurology,Xinyi People's Hospital,Guangdong Province,Yixin Guangdong,525300,China)
出处
《反射疗法与康复医学》
2021年第11期80-82,共3页
Reflexology And Rehabilitation Medicine
关键词
癫痫
丙戊酸钠
托吡酯
睡眠质量
神经递质
Epilepsy
Sodium valproate
Topiramate
Sleep quality
Neurotransmitter
作者简介
梁艳(1987-),女,广东信宜人,主治医师,本科,研究方向:神经内科临床。
