摘要
目的探讨在脑梗死患者中应用氯吡格雷联合阿司匹林治疗的效果.方法选择2019年4月—2021年4月我院收治的90例脑梗死患者,采用随机数字表法分为两组,各45例.对照组采用阿司匹林治疗,观察组在对照组基础上加用氯吡格雷治疗,均连续治疗2周.对比两组临床疗效、凝血活酶时间(APTT)、纤维蛋白原(FIB)、凝血酶原时间(PT)、美国国立卫生研究院卒中量表(NIHSS)评分及不良反应发生率.结果观察组临床总有效率95.56%高于对照组的80.00%,差异有统计学意义(P<0.05).观察组FIB水平、NIHSS评分分别为(1.96±0.23)g/L、(8.02±1.98)分,均低于对照组的(2.55±0.27)g/L、(13.84±2.33)分,APTT、PT分别为(37.25±3.54)s、(15.34±1.57)s,均长于对照组的(29.94±3.03)s、(12.28±1.29)s,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论氯吡格雷联合阿司匹林有助于改善脑梗死患者神经功能及凝血功能,提高临床疗效,且安全性高.
Objective To investigate the effect of clopidogrel combined with aspirin in patients with cerebral infarction.Methods A total of 90 patients with cerebral infarction admitted to our hospital from April 2019 to April 2021 were selected and divided into two groups by random number table method,with 45 cases in each group.The control group was treated with aspirin,and the observation group was additionally treated with clopidogrel on the basis of the control group,both for 2 consecutive weeks.The clinical efficacy,thromboplastin time(APTT),fibrinogen(FIB),prothrombin time(PT),National Institutes of Health Stroke Scale(NIHSS)score and incidence of adverse reactions were compared between the two groups.Results The total clinical effective rate of the observation group was 95.56%higher than 80.00%of the control group,and the difference was statistically significant(P<0.05).The FIB level and NIHSS score of the observation group were(1.96±0.23)g/L and(8.02±1.98)points,respectively,which were lower than(2.55±0.27)g/L and(13.84±2.33)points of the control group,the APTT and PT were(37.25±3.54)s and(15.34±1.57)s,respectively,which were longer than(29.94±3.03)s and(12.28±1.29)s in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Clopidogrel combined with aspirin can help improve the neurological function and coagulation function of patients with cerebral infarction,improve clinical efficacy,and has high safety.
作者
张勇
ZHANG Yong(Department of Encephalopathy,Linyi Hospital of Traditional Chinese Medicine,Linyi Shandong,276000,China)
出处
《反射疗法与康复医学》
2021年第20期94-96,共3页
Reflexology And Rehabilitation Medicine
关键词
脑梗死
氯吡格雷
阿司匹林
凝血功能
神经功能
Cerebral infarction
Clopidogrel
Aspirin
Coagulation function
Neurological function
作者简介
张勇(1975-),男,山东临沂人,本科,副主任医师,研究方向:神经内科临床。
