摘要
目的对比不同治疗方案在慢阻肺(COPD)稳定期的临床效果.方法选取本院2019年1月—2021年1月收治的93例COPD稳定期患者,以随机抽签法分作A组、B组及C组,每组31例.A组采用三联治疗,B组采用双支气管扩张剂治疗,C组采用吸入糖皮质激素治疗.比较三组的临床疗效及治疗前后的肺功能指标及血清炎症因子水平,统计三组的不良反应.结果B组的临床治疗总有效率为96.77%,高于A、C组,差异有统计学意义(P<0.05).治疗后,B组的各项肺功能指标水平均高于A、C组,组间差异有统计学意义(P<0.05).治疗后,B组的血清C反应蛋白及降钙素原水平均低于A、C组,组间差异有统计学意义(P<0.05).三组患者的恶心呕吐、口干、头痛发生率比较,组间差异无统计学意义(P>0.05).结论双支气管扩张剂方案在COPD稳定期患者中的临床疗效优于三联治疗及吸入糖皮质激素治疗,在改善患者肺功能及血清炎症因子水平方面的效果均较佳,值得临床推广使用.
Objective To compare the clinical effects of different treatment schemes in chronic obstructive pulmonary disease(COPD)stable stage.Methods A total of 93 COPD stable patients admitted to the hospital from January 2019 to January 2021 were selected and divided into group A,group B and group C according to a random lottery method,with 31 patients in each group.Group A received triple therapy,group B received double bronchodilators,and group C received inhaled corticosteroid.The clinical efficacy,lung function indexes and serum inflammatory factor levels before and after treatment were compared among the three groups,and the adverse reactions of the three groups were counted.Results The total effective rate of clinical treatment in group B was 96.77%,higher than that in group A and C,the differences were statistically significant(P<0.05).After treatment,the levels of lung function indexes in group B were higher than those in group A and C,and the differences between groups were statistically significant(P<0.05).After treatment,the levels of serum C-reactive protein and procalcitonin in group B were lower than those in groups A and C,the differences between groups were statistically significant(P<0.05).There were no significant differences in the incidence of nausea and vomiting,dry mouth and headache among 3 groups(P>0.05).Conclusion The clinical efficacy of dual bronchodilator regimen in stable COPD patients is superior to triple therapy and inhaled corticosteroid therapy,and it has better effects in improving lung function and serum inflammatory factor levels,which is worthy of clinical promotion.
作者
蒋晨成
邰艳秒
卢丽瑾
JIANG Chencheng;TAI Yanmiao;LU Lijin(Department of Respiratory Medicine,Baoding Second Central Hospital,Baoding Hebei,072750,China)
出处
《反射疗法与康复医学》
2021年第21期72-75,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性阻塞性肺疾病
三联
双支气管扩张剂
吸入糖皮质激素
临床疗效
Chronic obstructive pulmonary disease
Triple
Double bronchodilator
Inhaled corticosteroid
Clinical efficacy
作者简介
蒋晨成(1987-),女,河北涿州人,硕士研究生,主治医师,研究方向:支气管扩张、慢阻肺治疗。
