摘要
目的探究头孢噻肟钠联合舒巴坦钠治疗老年呼吸道感染患者对细菌清除率及治疗效果的影响.方法选择2020年6月—2021年12月盐城市妇幼保健院收治的104例老年呼吸道感染患者,按照随机数字表法分为对照组(n=52)和观察组(n=52).对照组静脉滴注头孢噻肟钠,观察组静脉滴注头孢噻肟钠联合舒巴坦钠,均持续治疗14 d.比较两组细菌清除效果、治疗效果、炎症因子水平及安全性.结果观察组治疗后的细菌清除率94.23%、治疗总有效率96.15%,均较对照组的80.77%、82.69%高,组间差异有统计学意义(P<0.05).治疗前,两组各项炎症因子水平比较,组间差异无统计学意义(P>0.05);治疗后,观察组降钙素原、白细胞、C反应蛋白水平分别为(0.52±0.10)μg/L、(8.54±1.45)×10^(9)/L、(8.29±1.31)mg/L,均低于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论在老年呼吸道感染患者中采用头孢噻肟钠联合舒巴坦钠治疗的效果确切,能够减轻感染症状,提高细菌清除率,缓解炎症反应,且安全可靠,具有临床进一步推广价值.
Objective To explore the effect of cefotaxime sodium combined with sulbactam sodium on bacterial clearance rate and therapeutic effect in elderly patients with respiratory tract infection.Methods A total of 104 elderly patients with respiratory tract infection who were admitted to Yancheng Maternal and Child Health Hospital from June 2020 to December 2021 were selected and divided into the control group(n=52)and the observation group(n=52)according to the random number table method.The control group was given intravenous drip of cefotaxime sodium,and the observation group was given intravenous drip of cefotaxime sodium combined with sulbactam sodium for 14 days.The bacterial removal effect,therapeutic effect,inflammatory factor levels and safety were compared between the two groups.Results After treatment,the bacterial clearance rate in the observation group was 94.23%,and the total effective rate was 96.15%,which were higher than those in the control group,which were 80.77%and 82.69%,and the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of various inflammatory factors between the two groups(P>0.05);after treatment,the levels of procalcitonin,white blood cells,and C-reactive protein in the observation group were(0.52±0.10)μg/L,(8.54±1.45)×10^(9)/L,and(8.29±1.31)mg/L,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Cefotaxime sodium combined with sulbactam sodium treatment in elderly patients with respiratory tract infection has exact effect,can reduce infection symptoms,improve bacterial clearance rate,relieve inflammatory response,and is safe and reliable,and has further clinical value.
作者
黄芝
叶丽诗
HUANG Zhi;YE Lishi(Department of Pharmacy,Yancheng Maternal and Child Health Hospital,Yancheng Jiangsu,224000,China)
出处
《反射疗法与康复医学》
2022年第9期145-147,154,共4页
Reflexology And Rehabilitation Medicine
关键词
呼吸道感染
头孢噻肟钠
舒巴坦钠
细菌清除率
治疗效果
炎症反应
安全性
Respiratory tract infection
Cefotaxime sodium
Sulbactam sodium
Bacterial clearance rate
Therapeutic effect
Inflammatory response
Safety
作者简介
黄芝(1987-),男,江苏盐城人,本科,主管药师,研究方向:临床药学。
