摘要
目的探讨柳氮磺胺吡啶联合康复新液治疗溃疡性结肠炎(UC)患者的具体疗效.方法选取该院2020年3月—2022年1月收治的78例UC患者为对象,按随机数字表法分为两组,各39例.对照组口服柳氮磺胺吡啶肠溶片治疗,观察组在对照组基础上加用康复新液治疗.比较两组治疗前、治疗4周后的肠道黏膜核因子KB(NF-KB)、Toll样受体4(TLR-4)及免疫功能指标水平,并评价临床疗效和安全性.结果治疗4周后,观察组肠道黏膜NF-KB、TLR-4水平和CD3^(+)、CD4^(+)/CD8^(+)较对照组更低,组间差异有统计学意义(P<0.05).观察组治疗总有效率92.31%较对照组的74.36%更高,差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论柳氮磺胺吡啶联合康复新液治疗UC能够抑制肠道黏膜NF-KB、TLR-4表达,增强免疫功能,安全有效.
Objective To explore the specific efficacy of sulfasalazine combined with Kangfuxin liquid in the treatment of patients with ulcerative colitis(UC).Methods A total of 78 UC patients admitted to the hospital from March 2020 to January 2022 were selected and divided into two groups according to the random number table method,with 39 cases in each group.The control group was treated with oral sulfasalazine enteric-coated tablets,and the observation group was additionally treated with Kangfuxin liquid on the basis of the control group.The levels of intestinal mucosal nuclear factor KB(NF-KB),Toll-like receptor 4(TLR-4)and immune function indexes were compared between the two groups before treatment and after 4 weeks of treatment,and the clinical efficacy and safety were evaluated.Results After 4 weeks of treatment,the levels of NF-KB,TLR-4 and CD3^(+),CD4^(+)/CD8^(+)in the intestinal mucosa of the observation group were lower than those of the control group,and the differences between the groups were statistically significant(P<0.05).The total effective rate of treatment in the observation group was 92.31%,higher than 74.36%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Sulfasalazine combined with Kangfuxin Liquid in the treatment of UC can inhibit the expression of NF-KB and TLR-4 in intestinal mucosa,and enhance immune function,which is safe and effective.
作者
侯朝军
HOU Chaojun(Department of Gastroenterology,People's Hospital of Yicheng District,Zaozhuang City,Zaozhuang Shandong,277300,China)
出处
《反射疗法与康复医学》
2022年第10期119-121,共3页
Reflexology And Rehabilitation Medicine
作者简介
侯朝军(1972-),男,山东枣庄人,本科,主治医师,研究方向:消化内科临床疾病。
