摘要
目的探讨麝香保心丸联合阿托伐他汀在急性心肌梗死(AMI)患者中的应用效果.方法选取2021年5月—2022年5月本院收治的AMI患者82例,按随机数字表法分为两组.对照组41例采用阿托伐他汀钙片治疗,观察组41例在对照组基础上采用麝香保心丸治疗,均持续2周.比较两组的左心室收缩末期容积(LVESV)、左心室舒张末期容积(LVEDV)及左室射血分数(LVEF),血清内皮素(ET)、血清一氧化氮(NO),C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α),临床疗效及不良反应发生情况.结果观察组的治疗总有效率为97.56%,高于对照组的80.49%,差异有统计学意义(P<0.05).治疗后,观察组的LVESV、LVEDV、ET水平分别为(75.98±11.25)mL、(125.22±13.26)mL、(5.07±1.05)μ/L,均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的CRP、IL-6、TNF-α水平均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的LVEF、NO水平均高于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论采用麝香保心丸联合阿托伐他汀治疗AMI的效果显著,能够有效改善患者心功能及血管内皮功能,减轻炎症反应,且安全性高.
Objective To investigate the clinical efficacy of Shexiang Baoxin Pill combined with atorvastatin in patients with acute myocardial infarction(AMI).Methods 82 patients with AMI admitted to our hospital from May 2021 to May 2022 were selected and were divided into two groups according to random number table method.The control group of 41 cases was treated with atorvastatin calcium tablets,and the observation group of 41 cases was treated with Shexiang Baoxin Pill on the basis of the control group.Both groups were treated for 2 weeks.The left ventricular end-systolic volume(LVESV),left ventricular end-diastolic volume(LVEDV),left ventricular ejection fraction(LVEF),serum endothelin(ET),serum nitric oxide(NO),C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),clinical efficacy and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 97.56%,which was higher than 80.49%of the control group,the difference was statistically significant(P<0.05).After treatment,the levels of LVESV,LVEDV and ET in the observation group were(75.98±11.25)mL,(125.22±13.26)mL and(5.07±1.05)μ/L,respectively,which were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of CRP,IL-6 and TNF-αin the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of LVEF and NO in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shexiang Baoxin Pill combined with atorvastatin has a significant effect in patients with AMI,which can effectively improve the cardiac function and vascular endothelial function,reduce inflammation,and have high safety.
作者
姬允龙
JI Yunlong(Department of Internal Medicine,Jining Municipal Government Hospital,Jining Shandong,272000,China)
出处
《反射疗法与康复医学》
2022年第21期12-15,共4页
Reflexology And Rehabilitation Medicine
关键词
急性心肌梗死
麝香保心丸
阿托伐他汀
心功能
血管内皮功能
炎症反应
Acute myocardial infarction
Shexiang Baoxin Pill
Atorvastatin
Cardiac function
Vascular endothelial function
Inflammatory reaction
作者简介
姬允龙(1988-),男,山东济宁人,本科,主治医师,研究方向:心血管内科临床.
