摘要
目的探究达格列净联合二甲双胍对2型糖尿病伴肥胖患者胰岛素抵抗、糖脂代谢、氧化应激的影响.方法选择本院2020年6月—2022年3月收治的88例2型糖尿病伴肥胖患者,按随机数字表法分为对照组、观察组,每组44例.对照组采用二甲双胍治疗,观察组在此基础上采用达格列净治疗,均持续3个月.比较两组的胰岛素抵抗、糖脂代谢、氧化应激情况及安全性.结果治疗后,观察组的空腹胰岛素水平为(11.36±1.69)mU/L,高于对照组的(9.21±1.57)mU/L,胰岛素抵抗指数为(1.42±0.22),低于对照组的(1.82±0.31),组间差异有统计学意义(P<0.05).治疗后,观察组的空腹血糖、糖化血红蛋白、低密度脂蛋白胆固醇水平均低于对照组,高密度脂蛋白胆固醇水平高于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的丙二醛、血清活性氧水平均低于对照组,超氧化物歧化酶水平高于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论采用达格列净联合二甲双胍治疗2型糖尿病伴肥胖患者,能有效减轻胰岛素抵抗及氧化应激反应,促进糖脂代谢,且安全可靠.
Objective To investigate the effects of dagliazine combined with metformin on insulin resistance,glycolipid metabolism and oxidative stress in patients with type 2 diabetes mellitus and obesity.Methods A total of 88 patients with type 2 diabetes mellitus and obesity admitted to the hospital from June 2020 to March 2022 were selected and were divided into a control group and an observation group according to random number table,with 44 cases in each group.The control group was treated with metformin,and the observation group was treated with dagliazine on this basis.Both groups lasted for 3 months.The insulin resistance,glycolipid metabolism,oxidative stress and safety of the two groups were compared.Results After treatment,the fasting insulin level of the observation group was(11.36±1.69)mU/L,higher than(9.21±1.57)mU/L of the control group,and the insulin resistance index was(1.42±0.22),lower than(1.82±0.31)of the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of fasting blood glucose,glycosylated hemoglobin and low density lipoprotein cholesterol in the observation group were lower than those in the control group,while the level of high density lipoprotein cholesterol was higher than that in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of malondialdehyde and serum reactive oxygen species in the observation group were lower than those in the control group,and the level of superoxide dismutase was higher than that in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Dagliazine combined with metformin in the treatment of type 2 diabetes mellitus with obesity can effectively reduce insulin resistance and oxidative stress response,promote glucose and lipid metabolism,and is safe and reliable.
作者
俞杨
YU Yang(Department of Endocrinology,The Third People's Hospital,Haimen District,Nantong City,Jiangsu Province,Nantong Jiangsu,226151,China)
出处
《反射疗法与康复医学》
2022年第22期80-82,86,共4页
Reflexology And Rehabilitation Medicine
关键词
2型糖尿病
肥胖
达格列净
二甲双胍
胰岛素抵抗
糖脂代谢指标
氧化应激
Type 2 diabetes mellitus
Obesity
Dagliazin
Metformin
Insulin resistance
Glycolipid metabolism indicators
Oxidative stress
作者简介
俞杨(1975-),男,江苏南通人,本科,副主任医师,研究方向:糖尿病诊治。
