摘要
目的探讨内窥镜手术联合枸地氯雷他定在慢性鼻窦炎(CS)患者中的应用效果.方法选择2019年11月—2021年3月于我院治疗的86例CS患者为研究对象,按随机数字表法将其分为两组,各43例.对照组采用内窥镜手术治疗,观察组于对照组基础上术前3d采用枸地氯雷他定治疗.比较两组临床疗效、鼻黏膜黏液纤毛传输系统功能、炎症因子水平、疼痛程度、鼻黏膜形态以及并发症发生情况.结果观察组治疗总有效率95.35%高于对照组的79.07%,差异有统计学意义(P<0.05).术后3个月,观察组鼻道黏液纤毛清除速率(7.34±1.66)mm/min高于对照组的(6.19±1.51)mm/min,白细胞介素-8(IL-8)(285.61±32.09)ng/L、白细胞介素-6(IL-6)(6.29±2.46)pg/mL、肿瘤坏死因子-α(TNF-α)(2.25±0.64)ng/mL均低于对照组的(321.71±39.67)ng/L、(9.87±3.68)pg/mL、(2.78±0.86)ng/mL,组间差异有统计学意义(P<0.05).术后3个月,观察组疼痛视觉模拟评分(1.86±0.82)分及改良Lund-Kennedy鼻内镜评分(1.46±0.62)分均低于对照组的(2.53±1.14)分、(1.88±0.91)分,组间差异有统计学意义(P<0.05).观察组并发症发生率4.65%低于对照组的18.60%,差异有统计学意义(P<0.05).结论CS患者采用内窥镜手术、枸地氯雷他定联合治疗是安全可行的,可降低IL-8、IL-6、TNF-α水平,抑制炎症反应,改善患者鼻黏液纤毛清除功能,减轻疼痛程度,减少并发症的发生,临床应用安全可靠.
Objective To investigate the application effect of endoscopic surgery combined with desloratadine citrate disodium in chronic rhinosinusitis(CS).Methods 86 patients with CS who were treated in the hospital from November 2019 to March 2021 were selected as the research objects and divided into two groups according to random number table method,43 patients in each group.The control group was treated with endoscopic surgery,and the observation group was treated with desloratadine citrate disodium 3 d before surgery on the basis of control group.The clinical efficacy,the transport system function of mucous cilia in nasal mucosa,the level of inflammatory factors,the degree of pain,the morphology of nasal mucosa and the incidence of complications were compared between the two groups.Results The total effective rate of the observation group was 95.35%,which was higher than 79.07%of the control group,and the difference was statistically significant(P<0.05).3 months after surgery,the mucociliary transport rate in nasal passages of the observation group was(7.34±1.66)mm/min,which was higher than(6.19±1.51)mm/min of the control group,the levels of interleukin-8,interleukin-6 and tumor necrosis factor-αin the observation group were(285.61±32.09)ng/L,(6.29±2.46)pg/mL and(2.25±0.64)ng/mL,respectively,which were lower than(321.71±39.67)ng/L,(9.87±3.68)pg/mL and(2.78±0.86)ng/mL in the control group,and the differences between the groups were statistically significant(P<0.05).3 months after surgery,the pain visual analogue scale score and modified Lund-Kennedy nasal endoscopy score of the observation group were(1.86±0.82)points and(1.46±0.62)points,respectively,which were lower than(2.53±1.14)points and(1.88±0.91)points of the control group,and the differences between the groups were statistically significant(P<0.05).The incidence of complications in the observation group was 4.65%,which was lower than 18.60%in the control group,and the difference was statistically significant(P<0.05).Conclusion Endoscopic surgery combined with desloratadine citrate disodium is safe and feasible for CS patients,which can reduce the levels of IL-8,IL-6 and TNF-α,inhibit inflammatory response,improve the clearance function of mucous cilia in nasal mucosa of patients,reduce the degree of pain,and reduce the occurrence of complications,and its clinical application is safe and reliable.
作者
伍润生
WU Runsheng(Department of Otolaryngology,Jiangsu Shuyang County Hospital of Traditional Chinese Medicine,Suqian Jiangsu,223600,China)
出处
《反射疗法与康复医学》
2023年第2期157-160,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性鼻窦炎
内窥镜手术
枸地氯雷他定
鼻黏液纤毛清除功能
炎症因子
并发症
Chronic rhinosinusitis
Endoscopic surgery
Desloratadine citrate disodium
Clearance function of mucous cilia in nasal mucosa
Inflammatory factors
Complication
作者简介
伍润生(1976-),男,江西分宜人,本科,副主任医师,研究方向:耳鼻咽喉相关疾病诊治。
