摘要
目的探讨桉柠蒎肠溶软胶囊联合头孢克肟对老年社区获得性肺炎(CAP)患者丙二醛(MDA)、醛固酮(ALD)、肺表面活性蛋白A(SP-A)水平的影响.方法选取2020年7月—2022年8月山东颐养健康集团莱芜中心医院收治的92例老年CAP患者为研究对象,按照随机数字表法将其分为对照组(n=46)和观察组(n=46).对照组采用头孢克肟治疗,观察组在对照组基础上采用桉柠蒎肠溶软胶囊治疗,两组均持续治疗14 d.观察两组的临床疗效,比较治疗前、治疗14 d后两组的肺功能、血清学指标水平,并记录两组不良反应发生率.结果观察组的治疗总有效率93.48%高于对照组的71.74%,差异有统计学意义(P<0.05).治疗前,两组的肺一氧化碳弥散量(DLCO)、用力肺活量(FVC)、第1秒用力呼气容积占预计值的百分比(FEV_(1)%pred)、血清丙二醛(MDA)、肺表面活性蛋白A(SP-A)、醛固酮(ALD)水平相比,组间差异无统计学意义(P>0.05);治疗14 d后,观察组的DLCO(3.89±0.62)mL/(kPa·s)、FVC(1.99±0.51)L均大于对照组的(3.28±0.48)mL/(kPa·s)、(1.77±0.43)L,FEV_(1)%pred(59.22±10.61)%高于对照组的(50.17±9.82)%,MDA水平(4.25±1.33)nmol/L、SP-A水平(16.33±5.71)μg/L、ALD水平(87.22±11.52)pg/mL均低于对照组的(9.21±1.87)nmol/L、(19.36±7.21)μg/L、(111.26±18.71)pg/mL,组间差异有统计学意义(P<0.05).观察组的不良反应发生率为4.35%,与对照组的8.70%相比,差异无统计学意义(P>0.05).结论采用桉柠蒎肠溶软胶囊联合头孢克肟治疗老年CAP的疗效确切,可明显改善患者的MDA、ALD、SP-A水平,促进肺功能提升,利于康复,且安全性高.
Objective To investigate the effect of Eucalyptus pinus enteric-coated soft capsule combined with cefixime on the levels of malondialdehyde(MDA),aldosterone(ALD)and pulmonary surfactant protein A(SP-A)in elderly patients with community-acquired pneumonia(CAP).Methods 92 elderly patients with CAP admitted to Laiwu Central Hospital of Shandong Yiyang Health Group from July 2020 to August 2022 were selected as the study subjects.They were divided into a control group(n=46)and an observation group(n=46)according to the method of random number table.The control group were treated with cefixime,and the observation group were treated with oral Eucalyptus pinus enteric-coated soft capsule on the basis of the control group.Both groups were treated for 14 days.The clinical efficacy of the two groups were observed,the lung function and serological indicator levels of the two groups before the treatment and after 14 d of the treatment were compared,and the incidence of adverse reactions of the two groups were recorded.Results The total effective rate of treatment 93.48%in the observation group was higher than 71.74%in the control group,with statistically significant difference(P<0.05).Before the treatment,there were no statistically significant differences between the two groups in the diffusion lung capacity for carbon monoxide(DLCO),forced vital capacity(FVC),forced expiratory volume in one second as a percentage of expected value(FEV_(1)%pred),serum malondialdehyde(MDA),pulmonary surfactant protein A(SP-A)and aldosterone(ALD)levels(P>0.05);after 14 d of the treatment,DLCO(3.89±0.62)mL/(kPa·s),FVC(1.99±0.51)L in the observation group were greater than(3.28±0.48)mL/(kPa·s),(1.77±0.43)L in the control group,FEV_(1)%pred(59.22±10.61)%was higher than(50.17±9.82)%in the control group,MDA level(4.25±1.33)nmol/L,SP-A level(16.33±5.71)μg/L,ALD level(87.22±11.52)pg/mL were lower than(9.21±1.87)nmol/L,(19.36±7.21)μg/L,(111.26±18.71)pg/mL in the control group,with statistically significant differences between the groups(P<0.05).The incidence of adverse reactions in the observation group was 4.35%,compared with 8.70%in the control group,there was no statistically significant difference(P>0.05).Conclusion Eucalyptus pinus enteric-coated soft capsule combined with cefixime is effective in the treatment of elderly CAP,which can significantly improve the level of MDA,ALD,SP-A in patients,promote the improvement of lung function,facilitate the rehabilitation,and has high safety.
作者
耿凤芹
公维梅
GENG Fengqin;GONG Weimei(Department of Pharmacy,Laiwu Central Hospital of Shandong Yiyang Health Group,Jinan Shandong,271103,China;Department of Respiratory,Laiwu Central Hospital of Shandong Yiyang Health Group,Jinan Shandong,271103,China)
出处
《反射疗法与康复医学》
2023年第3期83-85,123,共4页
Reflexology And Rehabilitation Medicine
关键词
社区获得性肺炎
桉柠蒎肠溶软胶囊
头孢克肟
肺功能
血清学指标
Community-Acquired pneumonia
Eucalyptus pinus enteric-coated soft capsule
Cefixime
Lung function
Serological indicators
作者简介
耿凤芹(1984-),女,山东济南人,本科,主管药师,研究方向:临床药学与药物不良反应监测。
