摘要
目的探讨复方金钱草颗粒辅助治疗在体外冲击波碎石术(ESWL)患者中的应用效果.方法选取2020年7月—2022年2月我院收治的94例肾结石患者为研究对象,按随机数字表法分为两组,每组47例.两组均行ESWL治疗,对照组采用常规辅助治疗,观察组在此基础上采用复方金钱草颗粒治疗.对比两组患者的临床疗效、排石情况、肾功能指标、中医症候积分、生活质量、结石复发率及不良反应发生情况.结果观察组的治疗总有效率为93.62%,高于对照组的78.72%,差异有统计学意义(P<0.05).观察组的结石首次排出时间、结石排净时间分别为(4.73±1.07)d、(6.50±1.52)d,均短于对照组的(6.54±1.49)d、(9.16±2.10)d,组间差异有统计学意义(P<0.05).治疗后,观察组的血肌酐、血清胱抑素C、β微球蛋白水平分别为(83.65±6.09)μmol/L、(537.77±42.21)μg/L、(0.95±0.17)mg/L,均高于对照组的(77.22±5.03)μmol/L、(503.36±36.69)μg/L、(0.71±0.16)mg/L,估算肾小球滤过率水平为(81.10±5.43)mL/(min·1.73m^(2)),中医症候积分为(5.10±1.22)分,均低于对照组的(86.22±5.75)mL/(min·1.73m^(2))、(8.90±1.75)分,组间差异有统计学意义(P<0.05).治疗后,观察组的生活质量综合评定问卷中躯体功能、心理功能、社会功能、物质生活状态评分分别为(85.13±5.44)分、(85.29±6.40)分、(80.10±5.26)分、(88.59±6.24)分,均高于对照组的(74.65±6.80)分、(78.38±5.81)分、(72.50±5.67)分、(80.42±5.05)分,组间差异有统计学意义(P<0.05).观察组的结石复发率为4.26%,低于对照组的19.15%,差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论复方金钱草颗粒辅助治疗ESWL的效果显著,能减轻肾结石患者的临床症状,改善其肾功能指标,并加快结石排出,减少疾病复发,提高患者的生活质量,安全性高.
Objective To investigate the effect of Compound Jinqiancao Granule adjuvant therapy on patients undergoing extracorporeal shock wave lithotripsy(ESWL).Methods 94 patients with kidney stones admitted to our hospital from July 2020 to February 2022 were selected as the research objects and were divided into two groups according to random number table method,with 47 cases in each group.Both groups were treated with ESWL,the control group was treated with conventional adjuvant therapy,and the observation group was treated with Compound Jinqiancao Granule on this basis.The clinical efficacy,stone discharge,renal function indexes,TCM syndrome score,quality of life,stone recurrence rate and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.62%,higher than 78.72%of the control group,the difference was statistically significant(P<0.05).The time of first stone expulsion and the time of clear stone expulsion in the observation group were(4.73±1.07)d and(6.50±1.52)d,respectively,which were shorter than(6.54±1.49)d and(9.16±2.10)d in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the serum creatinine,serum cystatin C andβmicroglobulin levels in the observation group were(83.65±6.09)μmol/L,(537.77±42.21)μg/L and(0.95±0.17)mg/L,respectively,which were higher than(77.22±5.03)μmol/L,(503.36±36.69)μg/L and(0.71±0.16)mg/L in the control group,while the estimated glomerular filtration rate was(81.10±5.43)mL/(min·1.73m^(2)),the TCM syndrome score was(5.10±1.22)points,which were lower than(86.22±5.75)mL/(min·1.73m^(2))and(8.90±1.75)points in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the scores of physical function,psychological function,social function and material life status in the generic quality of life inventory-74 of the observation group were(85.13±5.44)points,(85.29±6.40)points,(80.10±5.26)points and(88.59±6.24)points,respectively,which were higher than(74.65±6.80)points,(78.38±5.81)points,(72.50±5.67)points and(80.42±5.05)points in the control group,and the differences between the groups were statistically significant(P<0.05).The recurrence rate of stone in the observation group was 4.26%,lower than 19.15%in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compound Jinqiancao Granules have a significant effect in the adjuvant treatment of ESWL,which can reduce the clinical symptoms of patients with kidney stones,improve the renal function indexes,accelerate stone expulsion,reduce disease recurrence,improve the quality of life of patients with high safety.
作者
孙涛
吕文杰
孙付军
郭云良
SUN Tao;LYU Wenjie;SUN Fujun;GUO Yunliang(Department of Pharmacy,Pingyi County People's Hospital,Linyi Shandong,273300,China;Department of Urology,Pingyi County People's Hospital,Linyi Shandong,273300,China;School of Basic Medicine,Qingdao University,Qingdao Shandong,266000,China)
出处
《反射疗法与康复医学》
2023年第4期45-48,共4页
Reflexology And Rehabilitation Medicine
关键词
肾结石
复方金钱草颗粒
体外冲击波碎石术
临床疗效
排石情况
肾功能
Kidney stone
Compound Jinqiancao Granules
Extracorporeal shock wave lithotripsy
Clinical efficacy
Stone discharge
Renal function
作者简介
孙涛(1971-),男,山东临沂人,本科,副主任药师,研究方向:医院药学;通信作者:郭云良(1961-),男,山东青岛人,博士研究生,教授,研究方向:脑血管疾病的发病机制和防治,邮箱:guoqdsd@163.com。
