摘要
目的探讨有氧运动联合阿司匹林及氯吡格雷对老年冠心病患者心肌重塑和心功能恢复的影响.方法选择梁山县人民医院2019年1月—2022年1月收治的120例老年冠心病患者为研究对象,按随机数字表法分为两组.对照组(n=60)采用阿司匹林及氯吡格雷治疗,观察组(n=60)在此基础上进行有氧运动.对比两组患者的疗效、心功能、运动耐力、心肌重塑结果及炎症因子水平.结果治疗后,两组的左室射血分数(LVEF)、每搏输出量(SV)均较治疗前升高,左室收缩末期内径(LVESD)、左室舒张末期内径(LVEDD)均较治疗前降低,且观察组的LVEF、SV均高于对照组,LVESD、LVEDD均低于对照组,组间差异有统计学意义(P<0.05).治疗后,两组的峰值功率(PP)、峰值摄氧量(VO2peak)、无氧阈(AT)水平均较治疗前升高,且观察组的PP、VO2peak、AT水平均高于对照组,组间差异有统计学意义(P<0.05).治疗后,两组的超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平均较治疗前降低,且观察组的hs-CRP、IL-6、TNF-α水平分别为(2.35±0.49)mg/L、(11.61±2.34)ng/L、(4.56±1.05)mg/L,均低于对照组的(4.05±0.92)mg/L、(14.58±2.95)ng/L、(7.73±1.52)mg/L,组间差异有统计学意义(P<0.05).两组的治疗总有效率比较,差异无统计学意义(P>0.05).结论在采用阿司匹林及氯吡格雷治疗老年CHD时配合有氧运动,可改善患者心功能,抑制心肌重塑,减轻其炎症状态,值得临床推广使用.
Objective To investigate the effects of aerobic exercise combined with aspirin and clopidogrel on myocardial remodeling and cardiac function recovery in elderly patients with coronary heart disease.Methods 120 elderly patients with coronary heart disease admitted to Liangshan County People's Hospital from January 2019 to January 2022 were selected as the research objects and were grouped according to random number table method.60 cases in the control group were treated with aspirin and clopidogrel,and 60 cases in the observation group were treated with aerobic exercise on this basis.The efficacy,cardiac function,exercise endurance,myocardial remodeling results and inflammatory factor levels were compared between the two groups.Results After treatment,the left ventricular ejection fraction(LVEF)and stroke volume(SV)were increased than before treatment,while left ventricular end-systolic diameter(LVESD)and left ventricular end-diastolic diameter(LVEDD)were decreased than before treatment in both groups,and the LVEF and SV in the observation group were higher than those in the control group,while the LVESD and LVEDD were lower than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of peak power(PP),peak oxygen uptake(VO2peak)and anaerobic threshold(AT)in both groups were increased than before treatment,and the levels of PP,VO2peak and AT in the observation group were higher than those in the control group,the differences between the groups were statistically significant(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were decreased than before treatment in both groups,and the levels of hs-CRP,IL-6 and TNF-αin the observation group were(2.35±0.49)mg/L,(11.61±2.34)ng/L and(4.56±1.05)mg/L,respectively,which were lower than(4.05±0.92)mg/L,(14.58±2.95)ng/L and(7.73±1.52)mg/L in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).Conclusion Aspirin and clopidogrel combined with aerobic exercise in the treatment of CHD in elderly patients can improve the cardiac function,inhibit myocardial remodeling and reduce inflammation,and is worthy of clinical promotion.
作者
张峥
杨作祥
ZHANG Zheng;YANG Zuoxiang(1st Department of Cardiology,Liangshan County People's Hospital,Jining Shandong,272600,China)
出处
《反射疗法与康复医学》
2023年第5期93-96,共4页
Reflexology And Rehabilitation Medicine
关键词
冠心病
老年
阿司匹林
氯吡格雷
有氧运动
心功能
Coronary heart disease
Old age
Aspirin
Clopidogrel
Aerobic exercise
Cardiac function
作者简介
张峥(1985-),女,山东济宁人,硕士研究生,主治医师,研究方向:心血管内科常见病诊治。
