摘要
目的探究脑梗死后血管性认知障碍患者采用疏血通注射液联合艾地苯醌治疗对其神经功能及认知功能的影响。方法选择我院2021年6月—2022年8月收治的62例脑梗死后血管性认知障碍患者为研究对象,按随机数字表法分为两组,每组31例。对照组口服艾地苯醌,观察组在此基础上联合疏血通注射液,均治疗2周。对比两组患者的临床疗效、神经功能、认知功能、脑血流灌注情况及不良反应发生情况。结果观察组的治疗总有效率为93.55%,高于对照组的74.19%,差异有统计学意义(P<0.05)。观察组治疗后的美国国立卫生研究院卒中量表评分为(6.03±0.85)分,低于对照组,蒙特利尔认知评估量表评分为(25.73±1.31)分,高于对照组,组间差异有统计学意义(P<0.05)。观察组治疗后的脑血流容积、基底节区脑血流量分别为(2.51±0.25)mL/100 mg、(23.41±3.40)mL/100 mg·min,均高于对照组,脑血流平均通过时间为(6.84±0.35)s,短于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论脑梗死后血管性认知障碍患者采用疏血通注射液联合艾地苯醌治疗,可有效改善脑血流灌注、神经功能及认知功能,安全可靠,值得临床推广使用。
Objective To investigate the effect of Shuxuetong injection combined with idebenquinone on neural function and cognitive function in patients with vascular cognitive impairment after cerebral infarction.Methods 62 patients with vascular cognitive impairment after cerebral infarction admitted to the hospital from June 2021 to August 2022 were selected as the research objects and were divided into two groups according to random number table method,with 31 cases in each group.The control group was given idbenquinone,and the observation group was given Shuxuetong injection on this basis.Both groups were treated for 2 weeks.The clinical efficacy,neural function,cognitive function,cerebral blood perfusion and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 93.55%,which was higher than 74.19%of the control group,the difference was statistically significant(P<0.05).After treatment,the score of the National Institutes of Health stroke scale in the observation group was(6.03±0.85)points,which was lower than that of the control group,and the score of the Montreal cognitive assessment was(25.73±1.31)points,which was higher than that of the control group,and the differences between the groups were statistically significant(P<0.05).The cerebral blood flow volume and basal ganglia cerebral blood flow after treatment in the observation group were(2.51±0.25)mL/100 mg and(23.41±3.40)mL/100 mg·min,respectively,both higher than those in the control group,and the mean passage time of cerebral blood flow was(6.84±0.35)s,shorter than that in the control group,the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Shuxuetong injection combined with idebenquinone can effectively improve cerebral blood flow perfusion,neural function and cognitive function in patients with vascular cognitive impairment after cerebral infarction,and it is safe and reliable,worthy of clinical promotion.
作者
杨春燕
邵祥忠
YANG Chunyan;SHAO Xiangzhong(Department of Pharmacy,Haian People's Hospital,Haian Jiangsu,226600,China;Department of Neurology,Haian People's Hospital,Haian Jiangsu,226600,China)
出处
《反射疗法与康复医学》
2023年第11期8-10,共3页
Reflexology And Rehabilitation Medicine
关键词
脑梗死
血管性认知障碍
疏血通注射液
艾地苯醌
神经功能
认知功能
脑血流灌注
Cerebral infarction
Vascular cognitive impairment
Shuxuetong injection
Idebenquinone
Neural function
Cognitive function
Cerebral blood flow perfusion
作者简介
杨春燕(1990-),女,江苏滨海人,本科,初级药师,研究方向:内科药物疗效研究。
