摘要
目的分析布地奈德福莫特罗联合双水平气道正压通气在慢性阻塞性肺疾病(COPD)合并呼吸衰竭患者急诊治疗中的影响。方法选择2021年1月—2023年1月滨州市中心医院收治的120例COPD合并呼吸衰竭患者为研究对象,按电脑随机数字表法将其分为对照组和观察组,各60例。对照组采用双水平气道正压通气,观察组联用布地奈德福莫特罗,比较两组治疗前后的临床疗效、肺功能、动脉血气。结果观察组治疗总有效率为90.00%,高于对照组的75.00%,差异有统计学意义(P<0.05)。治疗前,两组第1秒用力呼气容积(FEV_(1))及占预计值的百分比(FEV_(1)/FVC%)、日排痰量比较,组间差异无统计学意义(P>0.05)。治疗后,观察组FEV_(1)、FEV_(1)/FVC%水平分别为(1.93±0.66)L、(90.62±5.55)%,均大于对照组的(1.72±0.21)L、(84.42±7.25)%,日排痰量少于对照组,组间差异有统计学意义(P<0.05)。治疗前,两组动脉血二氧化碳分压(PaCO_(2))和动脉血氧饱和度(SaO_(2))比较,组间差异无统计学意义(P>0.05)。治疗后,观察组SaO_(2)为(90.60±0.23)mmHg(1 mmHg=0.133 kPa),高于对照组的(86.25±0.29)mmHg,PaCO_(2)为(41.21±0.74)mmHg,低于对照组的(45.92±0.60)mmHg,组间差异有统计学意义(P<0.05)。结论关于COPD合并呼吸衰竭,布地奈德福莫特罗联合双水平气道正压通气有助于改善患者肺功能和动脉血气指标等临床症状,治疗安全性和实用性较高。
Objective To analyze the effect of budesonide/formoterol combined with bi-level positive airway pressure ventilation in the emergency treatment of patients with chronic obstructive pulmonary disease(COPD)complicated with respiratory failure.Methods 120 patients with COPD combined with respiratory failure admitted to Binzhou Central Hospital from January 2021 to January 2023 were selected as the study objects,and were divided into a control group and an observation group according to computer random number table method,with 60 cases in each group.The control group was treated with double-level positive airway pressure ventilation,and the observation group was treated with budesonide and formoterol.The clinical efficacy,pulmonary function and arterial blood gas of the two groups were compared before and after treatment.Results The total effective rate of the observation group was 90.00%,which was higher than 75.00%of the control group,the difference was statistically significant(P<0.05).Before treatment,forced expiratory volume in the first second(FEV_(1)),its percentage to the expected value(FEV_(1)/FVC%)and daily sputum output between the two groups had no statistical significance(P>0.05).After treatment,the levels of FEV_(1) and FEV_(1)/FVC%in the observation group were(1.93±0.66)L and(90.62±5.55)%,respectively,greater than(1.72±0.21)L and(84.42±7.25)%in the control group,and the daily sputum output was lower than that in the control group,with statistical significance between the two groups(P<0.05).Before treatment,there was no significant difference in arterial partial pressure of carbon dioxide(PaCO_(2))and arterial oxygen saturation(SaO_(2))between the two groups(P>0.05).After treatment,SaO_(2) in the observation group was(90.60±0.23)mmHg(1 mmHg=0.133 kPa),higher than(86.25±0.29)mmHg in the control group,PaCO_(2) was(41.21±0.74)mmHg,lower than(45.92±0.60)mmHg in the control group,and the difference between the groups was statistically significant(P<0.05).Conclusion For COPD complicated with respiratory failure,budesonide formoterol combined with bi-level positive airway pressure ventilation can help to improve the clinical symptoms of patients with pulmonary function and arterial blood gas indexes,and the treatment is safe and practical.
作者
马盼盼
MA Panpan(Department of Critical Care Medicine,Binzhou Central Hospital,Binzhou Shandong,251700,China)
出处
《反射疗法与康复医学》
2023年第19期106-109,共4页
Reflexology And Rehabilitation Medicine
关键词
慢性阻塞性肺疾病
布地奈德福莫特罗
双水平气道正压通气
呼吸衰竭
肺功能
Chronic obstructive pulmonary disease
Budesonide Fomotro
Bilateral positive airway pressure ventilation
Respiratory failure
Pulmonary function
作者简介
马盼盼(1989-),女,山东滨州人,硕士研究生,主治医师,研究方向:急危重症诊疗。
