摘要
目的探究重症病毒性肺炎患者使用奥司他韦治疗的效果。方法回顾性分析2021年1月—2023年1月于兰陵县人民医院接受治疗的80例重症病毒性肺炎患者的临床资料,按治疗方法不同分为对照组及观察组,每组40例。两组患者均接受常规对症治疗,在此基础上,对照组采用利巴韦林治疗,观察组采用奥司他韦治疗。对比两组患者的临床疗效、症状缓解时间、疾病严重程度、炎症因子水平及不良反应发生情况。结果观察组的治疗总有效率为95.00%,高于对照组的62.50%,差异有统计学意义(P<0.05)。观察组的乏力、发热、气促及憋喘等症状消失时间均短于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的氧合指数高于对照组,急性生理和慢性健康状况评分系统Ⅱ评分低于对照组,组间差异有统计学意义(P<0.05)。治疗后,观察组的白细胞介素-6、肿瘤坏死因子-ɑ、C反应蛋白水平均低于对照组,组间差异有统计学意义(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用奥司他韦治疗重症病毒性肺炎的效果确切,可减轻患者疾病严重程度,加速症状消失,减轻炎症反应,且不良反应较少,值得临床推广使用。
Objective To investigate the effect of oseltamivir in the treatment of severe viral pneumonia.Methods The clincal data of 80 patients with severe viral pneumonia admitted to Lanling County People's Hospital from January 2021 to January 2023 were retrospectively analyzed and were divided into a control group and an observation group according to different treatment methods,with 40 cases in each group.Both groups received conventional symptomatic treatment,on this basis,the control group was treated with ribavirin,while the observation group was treated with oseltamivir.The clinical efficacy,symptom remission time,disease severity,inflammatory factor levels and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.00%,which was higher than 62.50%of the control group,the difference was statistically significant(P<0.05).The disappearance time of fatigue,fever,shortness of breath and dyspnea in the observation group were shorter than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the oxygenation index of the observation group was higher than that of the control group,and the acute physiology and chronic health evaluation Ⅱ score was lower than that of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of interleukin-6,tumor necrosis factor-alpha and C-reactive protein in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Oseltamivir is effective in the treatment of severe viral pneumonia,which can reduce the severity of the disease,accelerate the disappearance of symptoms,relieve inflammation,and less adverse reactions.It is worthy of clinical promotion.
作者
房建珍
赵小君
张雪岷
FANG Jianzhen;ZHAO Xiaojun;ZHANG Xuemin(Department of Respiratory and Critical Care Medicine,Lanling County People's Hospital,Linyi Shandong,277700,China)
出处
《反射疗法与康复医学》
2023年第19期166-169,共4页
Reflexology And Rehabilitation Medicine
关键词
重症病毒性肺炎
奥司他韦
症状消失时间
炎症因子
Severe viral pneumonia
Oseltamivir
Time of symptom disappearance
Inflammatory factor
作者简介
房建珍(1982-),女,山东临沂人,硕士研究生,主治医师,研究方向:呼吸系统危重症疾病诊治;通信作者:张雪岷(1972-),男,山东兰陵人,本科,副主任医师,研究方向:呼吸系统危重症疾病诊治,邮箱:1657332478@qq.com。
