摘要
目的探讨柴胡加龙骨牡蛎汤配合针灸治疗脑卒中后抑郁(PSD)的临床效果。方法选取2020年1月—2022年12月我院收治的70例PSD患者为研究对象,按随机数字表法将其分为对照组与观察组,各35例。对照组采用西药治疗,观察组在对照组基础上加用柴胡加龙骨牡蛎汤配合针灸治疗,持续治疗4周。比较两组血清神经递质水平、抑郁情绪、中医证候积分及不良反应发生情况。结果治疗后,观察组5-羟色胺、多巴胺、去甲肾上腺素水平分别为(95.86±6.37)μg/mL、(695.41±50.14)nmol/L、(7.89±1.13)mmol/L,均高于对照组的(86.74±6.12)μg/mL、(648.74±46.68)nmol/L、(6.04±1.07)mmol/L,组间差异有统计学意义(P<0.05)。观察组汉密尔顿抑郁量表、抑郁自评量表评分分别为(6.12±1.02)分、(40.52±4.13)分,均低于对照组的(7.58±1.14)分、(45.37±4.28)分,组间差异有统计学意义(P<0.05)。观察组胸胁胀痛、情绪不宁、不思饮食、胸部痞满积分分别为(0.74±0.13)分、(0.85±0.14)分、(0.65±0.13)分、(0.59±0.12)分,均低于对照组的(0.95±0.15)分、(1.02±0.19)分、(0.84±0.14)分、(0.71±0.13)分,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论柴胡加龙骨牡蛎汤配合针灸可提高PSD治疗效果,纠正神经递质水平,消除抑郁情绪,降低中医证候积分,安全可靠。
Objective To explore the clinical effect of chaihu and Keel oyster decoction combined with acupuncture in the treatment of post-stroke depression(PSD).Methods 70 PSD patients admitted to our hospital from January 2020 to December 2022 were selected as the research objects.According to the random number table method,they were divided into a control group and an observation group,with 35 cases in each group.The control group was treated with western medicine,and the observation group was treated with Chaihu Longgu Oyster decoction combined with acupuncture and moxibustion on the basis of the control group,lasting for 4 weeks.The serum neurotransmitter levels,depression,TCM syndrome scores and adverse reactions were compared between the two groups.Results After treatment,the levels of 5-HT,DA and NE in the observation group were(95.86±6.37)μg/mL,(695.41±50.14)nmol/L and(7.89±1.13)mmol/L,respectively.The levels were higher than(86.74±6.12)μg/mL,(648.74±46.68)nmol/L,(6.04±1.07)mmol/L of the control group,the differences between the groups were statistically significant(P<0.05).The HAMD score and SDS score of the observation group were(6.12±1.02)points and(40.52±4.13)points,respectively,which were lower than(7.58±1.14)points and(45.37±4.28)points of the control group,and the differences between the two groups were statistically significant(P<0.05).In the observation group,the scores of chest and flank pain,emotional restlessness,diet and chest feeling were(0.74±0.13)points,(0.85±0.14)points,(0.65±0.13)points and(0.59±0.12)points.The scores were lower than(0.95±0.15)points,(1.02±0.19)points,(0.84±0.14)points,(0.71±0.13)points of the control group,the differences were statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Chaihu and Kegu Oyster Decoction combined with acupuncture can improve the effect of PSD treatment,correct the level of neurotransmitter,eliminate depression,reduce TCM syndrome score,safe and reliable.
作者
谭绍超
TAN Shaochao(Department 1 of Brain,Yantai Penglai Hospital of Traditional Chinese Medicine,Yantai Shandong,265600,China)
出处
《反射疗法与康复医学》
2023年第22期19-22,共4页
Reflexology And Rehabilitation Medicine
关键词
脑卒中后抑郁
柴胡加龙骨牡蛎汤
针灸
神经递质水平
抑郁情绪
Post-stroke depression
Chaihu plus Longgu oyster soup
Acupuncture and moxibustion
Neurotransmitter levels
Mood of depression
作者简介
谭绍超(1983-),男,山东烟台人,硕士研究生,主治医师,研究方向:中西医结合治疗睡眠障碍、焦虑抑郁状态。
