摘要
目的探讨在冠心病心绞痛(CHD-AP)患者中应用美托洛尔与单硝酸异山梨酯联合治疗对心肌酶谱及心绞痛发作的具体影响.方法选取我院2021年6月—2023年8月收治的86例CHD-AP患者为研究对象,按随机数字表法将其分为对照组与观察组,各43例.对照组采用单硝酸异山梨酯片治疗,观察组在对照组基础上加用美托洛尔片治疗,两组持续用药2个月.对比两组患者的临床疗效、心肌酶谱、心绞痛发作情况及不良反应发生情况.结果观察组治疗总有效率为95.35%,高于对照组的79.07%,差异有统计学意义(P<0.05).治疗后,观察组肌酸激酶(132.57±22.42)U/L、肌酸激酶同工酶(12.65±2.87)U/L、乳酸脱氢酶(165.76±20.65)U/L均低于对照组,心绞痛发作次数(2.53±0.25)次/周少于对照组,心绞痛持续时间(2.76±0.33)min/次短于对照组,组间差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论美托洛尔与单硝酸异山梨酯联合治疗CHD-AP患者可增强疗效、降低心肌酶谱,减少心绞痛的发作次数,缩短心绞痛持续时间,安全可靠.
Objective To explore the specific effects of the combination therapy of metoprolol and isosorbide mononitrate on myocardial enzyme spectrum and angina pectoris in patients with coronary heart disease angina pectoris(CHD-AP).Methods 86 CHD-AP patients admitted to our hospital from June 2021 to August 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 43 cases in each group.The control group was treated with isosorbide mononitrate tablets,and the observation group was treated with metoprolol tablets on the basis of the control group.The clinical efficacy,myocardial enzyme profile,angina pectoris attack and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 95.35%,higher than 79.07%of the control group,and the difference was statistically significant(P<0.05).After treatment,the creatine kinase(132.57±22.42)U/L,creatine kinase isoenzyme(12.65±2.87)U/L and lactate dehydrogenase(165.76±20.65)U/L in the observation group were lower than those in the control group,and the frequency of angina pectoris attacks(2.53±0.25)times/week was lower than that in the control group,the duration of angina pectoris(2.76±0.33)min/time was shorter than that of control group,and the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of metoprolol and isosorbide mononitrate in the treatment of CHD-AP patients can enhance efficacy,reduce myocardial enzyme spectrum,reduce the frequency of angina attacks,shorten the duration of angina,and is safe and reliable.
作者
穆林英
MU Linying(Department of Cardiology,Nanshan Hospital of Shandong Province,Jinan Shandong,250011,China)
出处
《反射疗法与康复医学》
2024年第2期81-83,87,共4页
Reflexology And Rehabilitation Medicine
关键词
冠心病心绞痛
美托洛尔
单硝酸异山梨酯
心肌酶谱
心绞痛发作
Coronary heart disease angina pectoris
Metoprolol
Isosorbide mononitrate
Myocardial enzyme spectrum
Angina attacks
作者简介
穆林英(1989-),女,山东济南人,硕士研究生,主治医师,研究方向:老年病诊治。
