摘要
目的探究酪酸梭菌二联活菌散配合蓝光照射治疗对高胆红素血症新生儿血清胆红素、炎症指标水平的影响.方法选取2022年8月—2023年8月聊城市东昌府区妇幼保健院收治的90例高胆红素血症新生儿为研究对象,按随机数字表法将其分为对照组与观察组,各45例.对照组采用蓝光照射治疗,观察组在对照组基础上加用酪酸梭菌二联活菌散治疗.比较两组患者的临床疗效、血清胆红素水平、炎症指标水平及不良反应发生情况.结果观察组治疗总有效率为93.33%,高于对照组的77.78%.治疗后,观察组总胆红素水平为(143.16±14.04)μmol/L,直接胆红素水平为(14.42±2.15)μmol/L,间接胆红素水平为(164.03±13.54)μmol/L,降钙素水平为(0.16±0.04)μg/L,C反应蛋白水平为(2.42±1.17)mg/L,白细胞介素-6水平为(11.03±1.34)ng/L,均低于对照组的(225.40±17.35)μmol/L、(18.74±2.25)μmol/L、(215.49±18.85)μmol/L、(0.20±0.05)μg/L、(5.74±1.25)mg/L、(15.49±1.35)ng/L,组间差异有统计学意义(P<0.05).两组不良反应发生率对比,差异无统计学意义(P>0.05).结论酪酸梭菌二联活菌散配合蓝光照射治疗可显著降低高胆红素血症新生儿血清胆红素水平安全性较高.
Objective To investigate the effects of Clostridium butyricum dual live powder combined with blue light irradiation on serum bilirubin and inflammatory markers in newborns with hyperbilirubinemia.Methods 90 neonates with hyperbilirubinemia treated in Dongchangfu Maternal and Child Health Hospital of Liaocheng City from August 2022 to August 2023 were selected as the study objects,and were divided into a control group and an observation group according to random number table method,with 45 cases in each group.The control group was treated with blue light irradiation,and the observation group was treated with Clostridium butyricum biactive powder on the basis of the control group.Results The total effective rate of observation group was 93.33%,which was higher than 77.78%of control group.After treatment,In the observation group,the total bilirubin level was(143.16±14.04)μmol/L,the direct bilirubin level was(14.42±2.15)μmol/L,the indirect bilirubin level was(164.03±13.54)μmol/L,the calcitonin level was(0.16±0.04)μg/L and the C-reactive protein level was(2.42±1.17)mg/L,interleukin-6 level was(11.03±1.34)ng/L,respectively,which were lower than(225.40±17.35)μmol/L,(18.74±2.25)μmol/L,(215.49±18.85)μmol/L,(0.20±0.05)μg/L,(5.74±1.25)mg/L,(15.49±1.35)ng/L of the control group,the differences between groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Clostridium butyricum dual live powder and blue light irradiation can significantly reduce serum bilirubin levels in neonates with hyperbilirubinemia,and the safety is relatively high.
作者
宋相菊
姚金秀
SONG Xiangju;YAO Jinxiu(Department of Neonatology,Dongchangfu District Maternal and Child Health Hospital,Liaocheng City,Liaocheng Shandong,252000,China;Department of Pediatrics,Dongchangfu District Traditional Chinese Medicine Hospital,Liaocheng City,Liaocheng Shandong,252000,China)
出处
《反射疗法与康复医学》
2024年第4期33-35,39,共4页
Reflexology And Rehabilitation Medicine
关键词
高胆红素血症
新生儿
酪酸梭菌二联活菌散
蓝光照射
血清胆红素
Hyperbilirubinemia
Newborns
Clostridium butyricum dual live bacterial powder
Blue light irradiation
Serum bilirubin
作者简介
宋相菊(1984-),女,山东聊城人,本科,主治医师,研究方向:新生儿疾病诊治;通信作者:姚金秀(1983-),女,山东聊城人,本科,主治医师,研究方向:儿科疾病诊治,邮箱:YJX830126@163.com。
