摘要
目的探讨依折麦布联合曲美他嗪对老年冠心病(CHD)患者颈动脉斑块性质、心功能及炎性因子的影响.方法选取2020年1月—2023年1月该院收治的82例老年CHD患者为研究对象,按照随机数字表法分为对照组和观察组,每组41例,其中对照组采用曲美他嗪治疗,观察组在对照组基础上采用依折麦布治疗.比较两组的临床疗效、动脉内膜-中层厚度(IMT)、斑块厚度(PT)、颈动脉内径、软斑块个数、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左室射血分数(LVEF)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及不良反应发生情况.结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05).治疗前,两组颈动脉斑块性质、心功能及炎性因子比较,组间差异无统计学意义(P>0.05);治疗后,两组IMT、PT均薄于治疗前,颈动脉内径短于治疗前,软斑块数少于治疗前,且观察组IMT、PT均薄于对照组,颈动脉内径短于对照组,软斑块数少于对照组,差异有统计学意义(P<0.05);治疗后,两组LVESD及LVEDD均短于治疗前,且观察组短于对照组,两组LVEF高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);治疗后,两组hs-CRP、IL-6及TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论老年CHD患者采用依折麦布联合曲美他嗪治疗,效果显著,可有效改善患者的颈动脉斑块性质,提高心功能,降低炎性因子水平,且较为安全.
Objective To explore the effects of ezetimibe combined with trimetazidine on carotid plaque properties,cardiac function and inflammatory factors in elderly patients with coronary heart disease(CHD).Methods 82 elderly CHD patients admitted to the hospital from January 2020 to January 2023 were selected as the research subjects,divided into a control group and an observation group using a random number table method,with 41 cases in each group.The control group was treated with trimetazidine,and the observation group received treatment with ezetimibe on the basis of the control group.The clinical efficacy,intima-media thickness(IMT),plaque thickness(PT),carotid artery internal diameter and number of soft plaques,left ventricular end systolic diameter(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and adverse reactions.Results The total effective rate in the observation group was higher than that in the control group the difference was statistically significant(P<0.05).Before treatment,comparison of properties,cardiac function,and inflammatory factors between two groups of carotid artery plaques,there was no statistically significant difference between groups(P>0.05).After treatment,the IMT and PT of the two groups were thinner than those before treatment,the carotid artery diameter was shorter than that before treatment,and the number of soft plaques was less than that before treatment,the IMT and PT of the observation group were thinner than those of the control group,the carotid artery diameter was shorter than that of the control group,and the number of soft plaques was less than that of the control group.the difference was statistically significant(P<0.05).After treatment,LVESD and LVEDD in both groups were shorter than before treatment,and the observation group was shorter than the control group,two groups of LVEF were higher than before treatment,and the observation group was higher than the control group,the differences were statistically significant(P<0.05).After treatment,two groups of hs-CRP,IL-6,and TNF-αlevels were all lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P<0.05).Comparison of incidence rates of adverse reactions between two groups,there was no statistically significant difference between groups(P>0.05).Conclusion Ezetimibe combined with trimetazidine is effective in the treatment of elderly CHD patients,which can effectively improve the properties of carotid plaque,improve cardiac function and reduce the level of inflammatory factors,and is relatively safe.
作者
王亚宁
薛冰
张文梅
WANG Yaning;XUE Bing;ZHANG Wenmei(Department of Internal Medicine,Dongchangfu District Traditional Chinese Medicine Hospital in Liaocheng City,Liaocheng Shandong,252000,China)
出处
《反射疗法与康复医学》
2024年第5期121-124,共4页
Reflexology And Rehabilitation Medicine
关键词
老年冠心病
依折麦布
曲美他嗪
颈动脉斑块性质
心功能
炎性因子
Elderly coronary heart disease
Ezetimibe
Trimetazidine
Carotid plaque properties
Cardiac function
Inflammatory factor
作者简介
王亚宁(1988-),女,河南濮阳人,本科,主治医师,研究方向:心血管疾病诊疗;通信作者:薛冰(1989),男,本科,主治医师,研究方向:心血管疾病诊疗,邮箱:xb15275666083@163.com。
