摘要
Nonalcoholic fatty liver disease(NAFLD)is regarded as the most frequent cause of chronic liver damage(1,2).The natural history of the disease presents a complex scenario of potential progression into severe clinical outcomes,including nonalcoholic steatohepatitis(NASH),NASH-fibrosis,cirrhosis,and hepatocellular carcinoma(1,2).In addition,NAFLD is closely associated with comorbidities of the metabolic syndrome(MetS),including type 2 diabetes,obesity,arterial hypertension,and dyslipidemia,which together aggravate the morbidity and mortality associated with the disease.
基金
Agencia Nacional de Promoción Científica y Tecnológica,Fondo para la Investigación Científica y Tecnológica(FonCyT)(PICT 2014-0432 and PICT 2015-0551 to SS and PICT 2014-1816 and 2016-0135 to CJ Pirola).
作者简介
Corresponding author:Carlos J.Pirola,PhD,Silvia Sookoian,MD,PhD.Instituto de Investigaciones Médicas(UBA-CONICET),Combatientes de Malvinas 3150,Ciudad Autónoma de Buenos Aires C1427ARN,Argentina.Email:pirola.carlos@conicet.gov.ar;Silvia Sookoian,Email:ssookoian@intramed.net.
