摘要
Objective: To investigate the pharmacodynamics of Qingyan granules. Methods: To investigate the efficancy of qingyan granules, the animal experience of maximum tolerated dose of mice was made. And the auricular swelling model of mice, the foot swelling model of rat, the phenol red secretion method, and the hot-plate and glacial acetic acid stimulation writhing method was established and used to test the anti-inflammatory effect, the expectorant effect, and the analgesia effect. Results: Pharmacodynamics experiment proved that the maximum dosage for mice was 42g/kg, the equivalent of 56 times for human. Qingyan granules has obvious inhibitory effect on mouse auricle swelling caused by xylene, and has obvious inhibitory effect on carrageenan-induced rat paw edem. Also, the mice pain caused by thermal and chemical stimulation has obviously inhibited by Qingyan granules. Qingyan granules can prolong the pain reaction time on mice caused by acetic acid. Conclusions: Qingyan granules have evident effects of anti-inflammatory effect, analgesic effect and expectorant effect.
