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Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease 被引量:4

Evaluation of Biomarkers in Egyptian Patients with Different Grades of Nonalcoholic Fatty Liver Disease
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摘要 Background and Aims:Nonalcoholic fatty liver disease (NAFLD) is a silent disease;its spectrum includes simple steatosis,nonalcoholic steatohepatitis and fibrosis.Pro-and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR).Moreover,plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD progression.Therefore,we aimed to detect biomarkers,ultrasonographic and anthropometric findings capable of differentiating NAFLD grades,since most previous investigators were concerned more with NAFLD patients without classifying them into grades.Methods:A total of 87 NAFLD patients (31 with grade 1 (mild NAFLD),26 with grade 2 (moderate NAFLD) and 30 with grade 3 (severe NAFLD) were included in the study,in addition to 47 controls (grade 0).All subjects underwent ultrasonographic examination for NAFLD diagnosis.Serum interleukin-10 (IL-10),plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent assay.Results:Homoeostasis model assessment (HOMA)-IR was higher in different NAFLD grades than in controls.Ultrasonographic and anthropometric findings and lipid profile indices (except for high-density lipoprotein cholesterol,which was decreased) were increased with NAFLD progression.Grade 3 patients showed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels when compared to grade 1 patients.Conclusion:Anthropometric and ultrasonographic findings were valuable in differentiating NAFLD grades.IR is very important in NAFLD pathogenesis.IL-18,HOMA-index and PC-1 levels could be used to differentiate between NAFLD grades,together with other measurements. Background and Aims:Nonalcoholic fatty liver disease (NAFLD) is a silent disease;its spectrum includes simple steatosis,nonalcoholic steatohepatitis and fibrosis.Pro-and anti-inflammatory cytokines play roles in the pathogenesis of NAFLD and insulin resistance (IR).Moreover,plasma cell antigen-1 (PC-1) is related to IR and associated with NAFLD progression.Therefore,we aimed to detect biomarkers,ultrasonographic and anthropometric findings capable of differentiating NAFLD grades,since most previous investigators were concerned more with NAFLD patients without classifying them into grades.Methods:A total of 87 NAFLD patients (31 with grade 1 (mild NAFLD),26 with grade 2 (moderate NAFLD) and 30 with grade 3 (severe NAFLD) were included in the study,in addition to 47 controls (grade 0).All subjects underwent ultrasonographic examination for NAFLD diagnosis.Serum interleukin-10 (IL-10),plasma interleukin-18 (IL-18) and plasma PC-1 levels were determined using enzyme-linked immunosorbent assay.Results:Homoeostasis model assessment (HOMA)-IR was higher in different NAFLD grades than in controls.Ultrasonographic and anthropometric findings and lipid profile indices (except for high-density lipoprotein cholesterol,which was decreased) were increased with NAFLD progression.Grade 3 patients showed significant increase in levels of IL-18 and significant decrease in IL-10 and PC-1 levels when compared to grade 1 patients.Conclusion:Anthropometric and ultrasonographic findings were valuable in differentiating NAFLD grades.IR is very important in NAFLD pathogenesis.IL-18,HOMA-index and PC-1 levels could be used to differentiate between NAFLD grades,together with other measurements.
出处 《Journal of Clinical and Translational Hepatology》 SCIE 2017年第2期109-118,共10页 临床与转化肝病杂志(英文版)
基金 Funding for this research was provided by the Egyptian National Research Center (Project Number 10010205)
关键词 NAFLD Interleukin-18(IL-18) Interleukin-10(IL-10) Plasma cell antigen-1(PC-1) NAFLD Interleukin-18(IL-18) Interleukin-10(IL-10) Plasma cell antigen-1(PC-1)
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