摘要
Background and Aims: Accumulated studies have eval-uated the effects of glucokinase regulatory protein(GCKR)gene polymorphisms on the risk of nonalcoholic fatty liver disease(NAFLD)and coronary artery disease(CAD),but the association of GCKR polymorphisms with the risk of NAFLD and CAD in the Chinese Han population have remained un-clear.The aim of this study was to investigate the association between GCKR gene polymorphisms(rs780094 and rs1260326)and the risk of NAFLD and CAD in NAFLD patients in a Chinese Northern Han population.Methods: GCKR rs780094 and rs1260326 gene polymorphisms were geno-typed by polymerase chain reaction sequencing for B-type ultrasonography-proven NAFLD patients with(n = 82)or without(n = 142)CAD,and in healthy controls(n = 152).Serum lipid profiles'levels were determined using biochemi-cal methods.Statistical analyses were conducted using SPSS 22.0 statistical software.Results: As the results showed,sig-nificant differences in the serum lipid profiles existed between each group.No significant differences were observed in the distributions of genotypes and alleles of GCKR rs780094 and rs1260326 in each group.The GCKR rs780094 T and rs1260326 T allele carriers possessed decreased body mass index value,and serum fasting plasma glucose and TG levels in the overall subjects,respectively.In addition,the GCKR rs780094 T allele carriers possessed decreased serum fasting plasma glucose level in the controls and NAFLD+CAD patients.Conclusions: GCKR rs780094 and rs1260326 poly-morphisms were found to be not associated with the risk of NAFLD nor of CAD in NAFLD patients in this Chinese Northern Han population.GCKR rs780094 T and rs1260326 T alleles could affect the body mass index value and serum fasting plasma glucose and triglyceride levels.
基金
This study was supported by grants from the National Natural Science Foundation of China(31770837)
the Qingdao People's Livelihood Science and Technology Plan(18-6-1-68-nsh)
作者简介
Corresponding author:Yongning Xin,Department of Infectious Disease,Qingdao Municipal Hospital,Qingdao University,1 Jiaozhou Road,Qingdao,Shandong 266011,China.Tel:+86-532-82789463,Fax:+86-532-85968434,E-mail:xinyongning@163.com;Corresponding author:Shiying Xuan,Department of Gastroenterology,Qingdao Municipal Hospital,Qingdao University,1 Jiaozhou Road,Qingdao,Shan­dong 266011,China.Tel:+86-532-88905508,Fax:+86-532-88905293,E-mail:xuansydxy@163.com
