摘要
Chronic hepatitis B or C viral infection is a common cause of liver cirrhosis and hepatocellular carcinoma. Fibrosis regres-sion can be achieved after long-term antiviral therapy (AVT). Monitoring of dynamic changes in liver fibrosis after treat-ment is essential for establishing prognosis and formulation of a follow-up surveillance program. Routine surveillance of fibrosis after AVT by liver biopsy, the gold standard for fibrosis assessment, is hindered by its invasive nature, sampling error and observer variability. Elastography is a noninvasive quan-titative alternative that has been widely used and validated for the staging of liver fibrosis prior to treatment. Recently, increasing research interest has been focused on the role of elastography in longitudinal assessment of liver fibrosis after AVT. In this review, the basic principles, acquisition techni-ques, diagnostic performances, and strengths and limitations of ultrasound elastography and magnetic resonance elastog-raphy are presented. Emerging evidence regarding the use of elastography techniques for the monitoring of liver fibrosis after AVT is summarized. Current challenges and future directions are also discussed, designed to optimize the application of these techniques in clinical practice.
基金
This work was supported by the National Natural Science Foundation of China(Grant No.81771797)
the 1.3.5 project for disciplines of excellence,West China Hospital,Sichuan University(Grant No.ZYJC18008).
作者简介
Correspondence to:Bin Song,Department of Radiology,West China Hospital of Sichuan University,No.37,Guoxue Alley,Chengdu,Sichuan 610041,China.Tel:+86-28-85423680,Fax:+86-28-85582499,E-mail:songlab_radiology@163.com
