摘要
Aldehyde dehydrogenase 2(ALDH2)is a key enzyme of alcohol metabolism and it is involved in the cellular mechanism of alcohol liver disease.ALDH2 gene mutations exist in about 8%of the world’s population,with the incidence reaching 45%in East Asia.The mutations will result in impairment of enzyme activity and accumulation of acetaldehyde,facilitating the progression of other liver diseases,including non-alcoholic fatty liver diseases,viral hepatitis and hepatocellular carcinoma,through adduct formation and inflammatory responses.In this review,we seek to summarize recent research progress on the correlation between ALDH2 gene polymorphism and multiple liver diseases,with an attempt to provide clues for better understanding of the disease mechanism and for strategy making.
基金
supported by the National Natural Science Foundation of China(NSFC),Grant numbers 81600467 and 81670527.
作者简介
Equal contribution:Qiaoling Wang;Equal contribution:Binxia Chang;Corresponding author:Zhengsheng Zou,The Center for Diagnosis and Treatment of Non-Infectious Liver Disease,The General Hospital of Chinese People’s Liberation Army No.5 Medical Science Center,No.100 Xisihuan Middle Road,Beijing 100039,China,E-mail:zszou302@163.com
